Naloxone HCL Nasal Spray 4mg

Generic For: Narcan

Naloxone HCL nasal spray 4mg (Narcan) is an opioid antagonist used for the emergency treatment of a known or suspected opioid overdose, including respiratory depression caused by opioids. It works by rapidly reversing the effects of opioids such as heroin, fentanyl, and prescription pain medications. After review by a licensed provider, your order ships from a licensed U.S. pharmacy.

Select Quantity *

2-day supply · $425.00/mL

How It Works

  1. Select your medication
  2. Licensed providers review & prescribe
  3. Our licensed U.S. pharmacists fill your prescription
  4. Delivered to you as soon as the next day

Price: $85.00

HSA/FSA Eligible
Get Started

*Doctor visit fee & delivery cost not included in price. Refills at provider discretion.

Pharmacist Support Fast Shipping Licensed U.S. Pharmacy

Buy Naloxone HCL Nasal Spray 4mg (Narcan) Online

An opioid antagonist nasal spray for emergency treatment of opioid overdose and opioid-induced respiratory depression

Naloxone HCL Nasal Spray 4mg Quick Facts

Drug classOpioid antagonist
TreatsOpioid overdose, opioid-induced respiratory depression
FormSpray
Typical dosingUse as directed on instruction sheet.
Prescription requiredYes — prescription only

What Is Naloxone HCL Nasal Spray 4mg?

Naloxone HCL nasal spray (brand name Narcan) is an opioid antagonist that rapidly reverses the effects of opioids in an emergency. It is used when someone shows signs of a known or suspected opioid overdose, such as slowed or stopped breathing, extreme drowsiness, or unresponsiveness. The spray is given into the nostril and requires no assembly or medical training to administer. Naloxone is not a substitute for emergency medical care — always call 911 after giving a dose.

What Does Naloxone HCL Nasal Spray 4mg Treat?

Emergency treatment of known or suspected opioid overdose
Opioid-induced respiratory depression
Overdose involving heroin or fentanyl
Overdose from prescription opioid pain medications
Central nervous system depression from opioids

Naloxone HCL Nasal Spray 4mg Dosage

Spray contents of 1 device (4 mg) into one nostril at first sign of suspected opioid overdose.
May repeat every 2–3 minutes with a new device, alternating nostrils, until emergency help arrives.
Call 911 immediately after administering the first dose.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Naloxone HCL Nasal Spray 4mg Side Effects

Common side effects

  • Increased blood pressure
  • Body aches
  • Nausea or vomiting
  • Sweating
  • Headache
  • Nasal dryness or congestion
  • Restlessness or irritability
  • Rapid heart rate

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

  • Severe opioid withdrawal symptoms (agitation, vomiting, diarrhea)
  • Seizures
  • Abnormal heart rhythms
  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Return of respiratory depression after naloxone wears off

Warnings & Interactions

Not a substitute for emergency medical care — call 911 after use
Opioid effects may return; repeat doses may be needed until help arrives
Can cause sudden, severe opioid withdrawal in opioid-dependent individuals
Withdrawal in opioid-dependent newborns may be life-threatening; monitor closely
Contraindicated in patients with known hypersensitivity to naloxone
Monitor the person continuously until emergency responders arrive

Tell your prescriber about all medications, supplements, and health conditions before starting naloxone hcl nasal spray 4mg.

Talk to U.S.-Based Support

Our licensed pharmacy team in Boca Raton, Florida — real people, no overseas call centers.

Frequently Asked Questions

What is naloxone HCL nasal spray used for?

Naloxone HCL nasal spray is used for the emergency treatment of a known or suspected opioid overdose, including opioid-induced respiratory depression. It rapidly reverses the effects of opioids such as heroin, fentanyl, and prescription pain medications while emergency help is on the way.

How do I use naloxone HCL nasal spray in an emergency?

Spray the full contents of one device (4 mg) into one nostril at the first sign of a suspected overdose, then call 911 immediately. If the person does not respond within 2–3 minutes, give another dose with a new device in the alternating nostril and continue until help arrives.

Do I need a prescription for Narcan nasal spray?

Yes, as offered here, naloxone HCL nasal spray 4mg requires a prescription. A licensed provider reviews your information before the medication is dispensed by our licensed U.S. pharmacy.

How does ordering and shipping work?

After you complete your order, a licensed provider reviews your health information to confirm the medication is appropriate. Once approved, your prescription ships from a licensed U.S. pharmacy in discreet packaging.

Is naloxone the same as Narcan?

Yes. Narcan is the brand name for naloxone HCL nasal spray. Both contain the same active ingredient, an opioid antagonist that reverses opioid overdose.

Does naloxone work on fentanyl overdoses?

Naloxone can reverse overdoses involving fentanyl, though stronger opioids may require repeat doses. Always call 911 after the first dose and continue dosing every 2–3 minutes as needed until emergency responders arrive.

What happens if naloxone is given to someone who hasn't taken opioids?

Naloxone has no significant effect in people who do not have opioids in their system. When in doubt during a suspected overdose, it is considered safer to administer it and call 911.