Prednisone 20mg

Generic For: Deltasone

Prednisone 20mg (brand name Deltasone) is a corticosteroid tablet that reduces inflammation and calms an overactive immune response. Providers often prescribe it for severe allergies, asthma flares, arthritis, and inflammation that can accompany infections such as sinus infections — sometimes alongside antibiotics like amoxicillin. After review by a licensed provider, your prescription ships from a licensed U.S. pharmacy.

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Buy Prednisone 20mg (Deltasone) Online

Corticosteroid for inflammation from sinus infections, allergic reactions, and asthma flares

Prednisone 20mg Quick Facts

Drug classCorticosteroid (glucocorticoid)
TreatsInflammation, severe allergies, asthma, arthritis
FormTablet
Typical dosingTake 3 tablets by mouth on day one, then 2 tablets daily for 5 days. Do not take with MethylPREDNIsolone 4mg.
Prescription requiredYes — prescription only

What Is Prednisone 20mg?

Prednisone is a prescription corticosteroid that works by lowering inflammation and suppressing immune system activity. It is used for a wide range of conditions, from severe allergic reactions and asthma to rheumatoid arthritis and inflammatory bowel disease. Many people search for prednisone together with antibiotics such as amoxicillin or azithromycin because providers sometimes prescribe both — the antibiotic treats the infection while prednisone reduces swelling and inflammation. Prednisone does not treat infections on its own and should be taken exactly as directed.

What Does Prednisone 20mg Treat?

Inflammation associated with respiratory conditions, including asthma
Severe allergic reactions and allergic states
Rheumatoid arthritis and other rheumatic disorders
Skin conditions such as severe psoriasis and dermatitis
Ulcerative colitis and Crohn's disease flares
Lupus and other autoimmune conditions
Certain blood disorders and adjunct cancer therapy

Prednisone 20mg Dosage

Take 5–60 mg by mouth once daily, individualized by condition and response.
Take with food to reduce stomach upset.
Do not stop abruptly after prolonged use; taper as directed by your provider.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Prednisone 20mg Side Effects

Common side effects

  • Increased appetite
  • Weight gain
  • Trouble sleeping (insomnia)
  • Mood changes or irritability
  • Stomach upset or indigestion
  • Fluid retention or swelling
  • Increased blood sugar
  • Headache

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

  • Signs of infection (fever, chills, sore throat)
  • Vision changes or eye pain
  • Severe mood changes, depression, or confusion
  • Black or bloody stools; vomiting blood
  • Severe allergic reaction (rash, swelling, trouble breathing)
  • Unusual fatigue or weakness after stopping (adrenal insufficiency)

Warnings & Interactions

Do not use if you have a systemic fungal infection
Do not stop suddenly after long-term use — taper under provider guidance
Can suppress the immune system and increase infection risk
Avoid live vaccines while taking immunosuppressive doses
May raise blood sugar; use caution with diabetes
Long-term use may cause bone loss, cataracts, or adrenal suppression
Tell your provider about NSAIDs, blood thinners, diuretics, and all other medicines

Tell your prescriber about all medications, supplements, and health conditions before starting prednisone 20mg.

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Frequently Asked Questions

Can you take prednisone and amoxicillin together?

Yes, providers commonly prescribe prednisone and amoxicillin together when an infection causes significant inflammation. The amoxicillin treats the bacterial infection while prednisone reduces swelling. Always take both exactly as prescribed and tell your provider about all medicines you use.

Why are amoxicillin and prednisone prescribed for sinus infection?

For some sinus infections, a provider may prescribe amoxicillin to treat the bacteria and a short course of prednisone to reduce sinus inflammation and swelling. This combination is used only when your provider decides it is appropriate; prednisone alone does not treat the infection.

Are amoxicillin and prednisone used for tooth infection?

A dentist or provider may prescribe amoxicillin for a bacterial tooth infection and, in select cases, prednisone to help control severe swelling. Prednisone is not a standard treatment for dental infections and is only used at a provider's discretion.

Can you take cyclobenzaprine and prednisone together?

There is no major known interaction between cyclobenzaprine and prednisone, and they are sometimes prescribed together, such as for back pain with inflammation. Still, confirm the combination with your provider or pharmacist, since your full medication list and health history matter.

Can you take azithromycin and prednisone together?

Azithromycin and prednisone are sometimes prescribed together, for example during respiratory illness with significant inflammation. Follow your provider's directions for both medicines and report any unusual symptoms such as irregular heartbeat.

Do I need a prescription for Prednisone 20mg?

Yes, prednisone is a prescription-only medication in the U.S. A licensed provider must review your health information and determine that it is appropriate before it can be dispensed.

How does ordering and shipping work?

After you place your order, a licensed provider reviews your information or your existing prescription is verified. Once approved, your Prednisone 20mg tablets ship from a licensed U.S. pharmacy in discreet packaging with tracking.