Do I need a prescription for eplerenone?

Yes. Eplerenone is a prescription-only medication in the United States. A licensed healthcare provider must review your health information and issue or verify a valid prescription before we can dispense it.

How does ordering and shipping work?

Place your order and provide your prescription, or have your provider send it to our pharmacy. Once a licensed pharmacist verifies the prescription, your medication ships from our licensed U.S. pharmacy in discreet packaging.

Is eplerenone the same as Inspra?

Yes. Eplerenone is the generic name for the brand-name drug Inspra. Generic eplerenone contains the same active ingredient at the same strength and is FDA-approved as equivalent.

How should I take eplerenone 50mg?

Take eplerenone exactly as prescribed, usually once or twice daily, with or without food. Do not change your dose or stop taking it without talking to your provider, and avoid potassium supplements or salt substitutes unless your provider approves.

What should I avoid while taking eplerenone?

Avoid grapefruit juice, potassium supplements, and salt substitutes containing potassium unless your provider says otherwise. Tell your provider about all medications you take, especially antifungals, certain antibiotics, ACE inhibitors, ARBs, and NSAIDs, as they can raise potassium or eplerenone levels.

What are the most common side effects of eplerenone?

Common side effects include dizziness, diarrhea, cough, fatigue, and increased potassium levels. Contact your provider promptly if you experience muscle weakness, an irregular heartbeat, or severe dizziness, as these can signal high potassium.

Eplerenone 50mg

Name: Eplerenone 50mg
Brand: All Family Pharmacy
SKU: eplerenone-50mg
Availability: InStock

Generic For: Inspra

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Eplerenone 50mg (brand name Inspra) is a prescription aldosterone antagonist tablet used to treat high blood pressure and to improve survival in patients with heart failure following a heart attack. After a licensed provider reviews your prescription, your order ships directly from a licensed U.S. pharmacy.

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Buy Eplerenone 50mg Online

Eplerenone (Inspra) is an aldosterone antagonist used for high blood pressure and heart failure after a heart attack.

Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge

Eplerenone 50mg Quick Facts

Drug class	Aldosterone antagonist
Treats	High blood pressure, heart failure after heart attack
Form	Tablet
Typical dosing	Take 1 tablet by mouth daily.
Prescription required	Yes — prescription only

What Is Eplerenone 50mg?

Eplerenone is a prescription medication known as an aldosterone antagonist, a type of potassium-sparing diuretic. It works by blocking aldosterone, a hormone that can raise blood pressure and cause the body to retain salt and water. Eplerenone is FDA-approved to treat high blood pressure and to improve survival in people with heart failure and reduced heart function after a heart attack. It is the generic version of the brand-name drug Inspra and is taken as a tablet, usually once or twice daily.

What Does Eplerenone 50mg Treat?

High blood pressure (hypertension)
Heart failure with reduced ejection fraction after a heart attack
Improving survival after myocardial infarction with left ventricular dysfunction
Blood pressure control alone or with other antihypertensive medicines

Eplerenone 50mg Dosage

Heart failure post-MI: 25 mg by mouth once daily; titrate to 50 mg once daily within 4 weeks as tolerated.
Hypertension: 50 mg by mouth once daily; may increase to 50 mg twice daily if response is inadequate after 4 weeks.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Eplerenone 50mg Side Effects

Common side effects

Dizziness
Diarrhea
Cough
Fatigue
Flu-like symptoms
Increased potassium levels
Abdominal pain
Increased creatinine

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

High potassium (hyperkalemia) — muscle weakness, irregular heartbeat
Severe dizziness or fainting
Signs of kidney problems (decreased urination, swelling)
Chest pain or irregular heart rhythm
Allergic reaction (rash, swelling, difficulty breathing)

Warnings & Interactions

Do not use with serum potassium >5.5 mEq/L at initiation
Contraindicated with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole)
Contraindicated in severe kidney impairment (CrCl <30 mL/min)
For hypertension: avoid in type 2 diabetes with microalbuminuria and in moderate renal impairment
Avoid potassium supplements and potassium-sparing diuretics unless directed by your provider
Monitor serum potassium and kidney function periodically
Use caution with ACE inhibitors, ARBs, and NSAIDs due to hyperkalemia risk

Tell your prescriber about all medications, supplements, and health conditions before starting eplerenone 50mg.