Lisinopril-Hydrochlorothiazide 20-12.5 MG

Generic For: Zestoretic

Lisinopril-hydrochlorothiazide 20-12.5 mg (Zestoretic) combines an ACE inhibitor with a thiazide diuretic in one tablet to help lower high blood pressure. It is typically prescribed when blood pressure is not adequately controlled with a single medication. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.

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Buy Lisinopril-Hydrochlorothiazide 20-12.5 MG Online

ACE inhibitor and thiazide diuretic combination tablet for high blood pressure (hypertension)

Lisinopril-Hydrochlorothiazide 20-12.5 MG Quick Facts

Drug classACE inhibitor / thiazide diuretic
TreatsHigh blood pressure (hypertension)
FormTablet
Typical dosingTake 1 tablet by mouth daily.
Prescription requiredYes — prescription only

What Is Lisinopril-Hydrochlorothiazide 20-12.5 MG?

Lisinopril-hydrochlorothiazide is a combination tablet containing two blood pressure medicines. Lisinopril is an ACE inhibitor that relaxes blood vessels, while hydrochlorothiazide is a thiazide diuretic (water pill) that helps the body eliminate excess salt and fluid. Together, they lower blood pressure more effectively than either medicine alone for many patients. The 20-12.5 mg strength contains 20 mg of lisinopril and 12.5 mg of hydrochlorothiazide and is taken once daily as directed by your provider.

What Does Lisinopril-Hydrochlorothiazide 20-12.5 MG Treat?

High blood pressure (hypertension)
Hypertension not controlled by lisinopril alone
Hypertension not controlled by hydrochlorothiazide alone
Lowering blood pressure to reduce risk of cardiovascular events, such as stroke and heart attack

Lisinopril-Hydrochlorothiazide 20-12.5 MG Dosage

Take 1 tablet by mouth once daily.
Dose may be titrated by your provider based on blood pressure response.
Maximum: lisinopril 80 mg / hydrochlorothiazide 50 mg per day.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Lisinopril-Hydrochlorothiazide 20-12.5 MG Side Effects

Common side effects

  • Dizziness or lightheadedness
  • Headache
  • Dry, persistent cough
  • Fatigue
  • Nausea
  • Low blood pressure (hypotension)
  • Muscle cramps

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Fainting or severe dizziness
  • Signs of high potassium (irregular heartbeat, muscle weakness)
  • Signs of kidney problems (reduced urination, swelling)
  • Severe skin reactions or signs of allergic reaction
  • Eye pain or sudden vision changes (acute angle-closure glaucoma)

Warnings & Interactions

Do not use during pregnancy — can cause injury or death to a developing fetus
Contraindicated with a history of angioedema related to ACE inhibitors
Do not take with or within 36 hours of sacubitril/valsartan (Entresto)
Contraindicated in patients with anuria or sulfonamide allergy
Avoid combining with aliskiren in patients with diabetes
Use caution with potassium supplements, potassium-sparing diuretics, lithium, and NSAIDs
Monitor kidney function and electrolytes during treatment

Tell your prescriber about all medications, supplements, and health conditions before starting lisinopril-hydrochlorothiazide 20-12.5 mg.

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Frequently Asked Questions

Do I need a prescription for lisinopril-hydrochlorothiazide 20-12.5 mg?

Yes, this medication requires a valid prescription in the U.S. A licensed provider must evaluate whether it is appropriate for your blood pressure before it can be dispensed.

What is lisinopril-hydrochlorothiazide 20-12.5 mg used for?

It is FDA-approved to treat high blood pressure (hypertension). It is generally prescribed when blood pressure is not adequately controlled with one medication alone.

How does ordering and shipping work?

Submit your prescription or have your provider send it to our pharmacy, and a pharmacist will review it before dispensing. Once verified, your order ships from a licensed U.S. pharmacy directly to your address.

Is lisinopril-hydrochlorothiazide the same as Zestoretic?

Yes, Zestoretic is the brand name for the combination of lisinopril and hydrochlorothiazide. The generic tablet contains the same active ingredients in the same strengths.

How should I take this medication?

Take one tablet by mouth once daily, at about the same time each day, exactly as prescribed. Do not stop taking it without talking to your provider, even if you feel well, since high blood pressure often has no symptoms.

Can I take lisinopril-hydrochlorothiazide while pregnant?

No. This medication can cause serious harm to a developing fetus and should be stopped as soon as pregnancy is detected. Tell your provider right away if you are pregnant or planning to become pregnant.

What should I do if I miss a dose?

Take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at once to make up for a missed dose.