What is losartan-hydrochlorothiazide 100-25 MG used for?

It is used to treat high blood pressure and to reduce the risk of stroke in certain patients with hypertension and an enlarged heart muscle (left ventricular hypertrophy). It combines two blood pressure medicines — an ARB and a diuretic — in one tablet.

Is losartan-hydrochlorothiazide 100 the same as Hyzaar?

Yes. Hyzaar is the brand name for losartan-hydrochlorothiazide, and the 100-25 MG strength contains 100 mg of losartan and 25 mg of hydrochlorothiazide. The generic works the same way as the brand.

Do I need a prescription for losartan-hydrochlorothiazide?

Yes, this medication requires a valid prescription in the United States. A licensed provider must review your health information and prescription before it can be dispensed.

How does ordering and shipping work?

After you place your order, a licensed provider reviews your prescription and health details. Once approved, your medication is filled and shipped from a licensed U.S. pharmacy to your address.

How should I take losartan-hydrochlorothiazide 100-25 MG?

Take one tablet by mouth once daily, with or without food, exactly as prescribed. Do not stop taking it without talking to your prescriber, even if you feel well.

Can I take this medication during pregnancy?

No. This medication carries a boxed warning because it can cause serious injury or death to a developing fetus. Tell your provider right away if you become pregnant or plan to become pregnant.

What should I avoid while taking this medication?

Avoid potassium supplements or salt substitutes containing potassium unless your prescriber approves. Limit alcohol, use caution with NSAIDs like ibuprofen, and tell your provider about all medications you take, including lithium.

Losartan-Hydrochlorothiazide 100-25 MG

Name: Losartan-Hydrochlorothiazide 100-25 MG
Brand: All Family Pharmacy
SKU: losartan-hydrochlorothiazide-100-25-mg
Availability: InStock

Generic For: Hyzaar

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Losartan-Hydrochlorothiazide 100-25 MG — All Family Pharmacy

Losartan-hydrochlorothiazide 100-25 MG (brand name Hyzaar) combines an angiotensin II receptor blocker with a thiazide diuretic in a single tablet to treat high blood pressure. It is also used to lower the risk of stroke in certain patients with hypertension and left ventricular hypertrophy. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.

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An angiotensin II receptor blocker and thiazide diuretic combination for high blood pressure and stroke risk reduction

Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge

Losartan-Hydrochlorothiazide 100-25 MG Quick Facts

Drug class	ARB / thiazide diuretic combination
Treats	High blood pressure, stroke risk reduction
Form	Tablet
Typical dosing	Take 1 tablet by mouth daily.
Prescription required	Yes — prescription only

What Is Losartan-Hydrochlorothiazide 100-25 MG?

Losartan-hydrochlorothiazide 100-25 MG is a prescription combination tablet containing losartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a thiazide diuretic. Losartan relaxes blood vessels by blocking a hormone that narrows them, while hydrochlorothiazide helps the body remove excess salt and water. Together, they lower blood pressure more effectively than either medicine alone. It is sold under the brand name Hyzaar and is typically used when a single medication has not controlled blood pressure adequately.

What Does Losartan-Hydrochlorothiazide 100-25 MG Treat?

High blood pressure (hypertension)
Hypertension not adequately controlled by one medication
Initial therapy for severe hypertension when rapid control is needed
Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy

Losartan-Hydrochlorothiazide 100-25 MG Dosage

Take 1 tablet (100-25 MG) by mouth once daily.
Usual starting dose for the combination is 50-12.5 MG once daily; 100-25 MG is the maximum daily dose.
Dose is titrated by the prescriber based on blood pressure response.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Losartan-Hydrochlorothiazide 100-25 MG Side Effects

Common side effects

Dizziness
Upper respiratory infection symptoms
Fatigue
Back pain
Cough
Increased urination
Lightheadedness when standing

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

Fainting or severe dizziness (symptomatic hypotension)
Signs of high potassium (muscle weakness, irregular heartbeat)
Swelling of face, lips, tongue, or throat (angioedema)
Signs of kidney problems (decreased urination, swelling)
Eye pain or sudden vision changes (acute angle-closure glaucoma)
Severe skin reactions or signs of electrolyte imbalance

Warnings & Interactions

Do not use during pregnancy — can cause injury or death to a developing fetus (boxed warning)
Contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs
Do not combine with aliskiren in patients with diabetes
May cause low blood pressure, especially in volume- or salt-depleted patients
Monitor electrolytes and kidney function; risk of high potassium and other imbalances
NSAIDs may reduce effectiveness and worsen kidney function
Use caution with lithium — levels may increase

Tell your prescriber about all medications, supplements, and health conditions before starting losartan-hydrochlorothiazide 100-25 mg.