What is naltrexone used for?

Naltrexone is FDA-approved to treat alcohol dependence and to block the effects of opioids in people who have completed opioid detoxification. It is intended to be used as part of a comprehensive treatment program that includes counseling and support.

Is naltrexone an opioid or addictive?

No. Naltrexone is an opioid antagonist, meaning it blocks opioid receptors rather than activating them. It is not habit-forming and does not produce a high or cause withdrawal when discontinued.

Do I need a prescription for naltrexone?

Yes. Naltrexone 50mg is a prescription-only medication in the United States. A licensed provider must evaluate you and issue a valid prescription before we can dispense it.

How does ordering and shipping work?

After you submit your prescription or complete a provider consultation, a licensed pharmacist reviews your order. Once approved, your medication ships directly from a licensed U.S. pharmacy to your address.

How long do I need to be off opioids before starting naltrexone?

You should typically be opioid-free for at least 7–10 days before starting naltrexone. Taking it too soon can trigger sudden, severe opioid withdrawal, so your provider may confirm you are opioid-free before you begin.

Does naltrexone stop alcohol cravings?

Naltrexone can reduce alcohol cravings and heavy drinking in many patients, though individual results vary. It works best when combined with counseling and a structured treatment program.

What is the difference between naltrexone tablets and Vivitrol?

Naltrexone 50mg tablets (brand ReVia) are taken by mouth once daily, while Vivitrol is a long-acting injectable form given monthly by a healthcare professional. Your provider can help determine which formulation fits your treatment plan.

Naltrexone 50mg

Name: Naltrexone 50mg
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Generic For: Vivitrol / ReVia

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Naltrexone 50mg (brand names ReVia, Vivitrol) is a prescription opioid antagonist used to support recovery from alcohol dependence and opioid dependence. It works by blocking the effects of opioids and reducing alcohol cravings in many patients. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.

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An opioid antagonist for alcohol dependence and opioid dependence

Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge

Naltrexone 50mg Quick Facts

Drug class	Opioid antagonist
Treats	Alcohol dependence, opioid dependence
Form	Tablet
Typical dosing	Take 1 tablet by mouth daily. Do not take opioids with these medications, and Limit alcohol consumption.
Prescription required	Yes — prescription only

What Is Naltrexone 50mg?

Naltrexone is a prescription medication that blocks opioid receptors in the brain. In people with alcohol dependence, it can reduce cravings and help decrease heavy drinking as part of a comprehensive treatment program. In people with opioid dependence, it blocks the euphoric effects of opioids after detoxification, helping prevent relapse. Naltrexone is not an opioid, is not habit-forming, and does not cause withdrawal when stopped.

What Does Naltrexone 50mg Treat?

Alcohol dependence (as part of a treatment program)
Blockade of the effects of opioids after detoxification
Prevention of relapse to opioid dependence
Maintenance of an opioid-free state in detoxified patients

Naltrexone 50mg Dosage

Alcohol dependence: 50 mg by mouth once daily.
Opioid dependence: 50 mg by mouth once daily after 7–10 days opioid-free; confirm opioid-free status before starting.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Naltrexone 50mg Side Effects

Common side effects

Nausea
Headache
Dizziness
Fatigue
Insomnia
Anxiety or nervousness
Abdominal pain or cramps
Joint or muscle pain

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

Signs of liver injury (dark urine, yellowing of skin or eyes, severe abdominal pain)
Precipitated opioid withdrawal (agitation, sweating, vomiting)
Severe allergic reaction (rash, swelling, trouble breathing)
New or worsening depression or suicidal thoughts
Severe injection-site reactions (extended-release form)

Warnings & Interactions

Do not use if currently taking opioids or in acute opioid withdrawal
Must be opioid-free for 7–10 days before starting to avoid precipitated withdrawal
Increased sensitivity to opioids after treatment raises overdose risk if opioids are resumed
May cause liver injury; use caution in liver disease and report symptoms promptly
Blocks opioid pain medications; alternative pain management may be needed in emergencies
Contraindicated with opioid analgesics, methadone, and buprenorphine
Tell your provider if you are pregnant, breastfeeding, or have kidney or liver problems

Tell your prescriber about all medications, supplements, and health conditions before starting naltrexone 50mg.