Naltrexone/Bupropion 8mg/90mg
Generic For: Contrave
Naltrexone/bupropion 8mg/90mg, sold under the brand name Contrave, is a prescription combination medication approved for chronic weight management in adults with obesity, or overweight with at least one weight-related condition such as high blood pressure or type 2 diabetes. It is used alongside a reduced-calorie diet and increased physical activity. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.
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60-day supply · $2.00/capsule
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Buy Naltrexone/Bupropion 8mg/90mg (Contrave) Online
A combination opioid antagonist and aminoketone antidepressant for chronic weight management in adults with obesity or overweight
Naltrexone/Bupropion 8mg/90mg Quick Facts
| Drug class | Opioid antagonist / aminoketone combination |
|---|---|
| Treats | Chronic weight management, obesity, overweight with weight-related conditions |
| Form | Capsule |
| Typical dosing | Take 1 capsule by mouth twice daily. |
| Prescription required | Yes — prescription only |
What Is Naltrexone/Bupropion 8mg/90mg?
Naltrexone/bupropion is a prescription combination medication marketed as Contrave. It pairs naltrexone, an opioid antagonist, with bupropion, an aminoketone antidepressant, and the two are thought to work on areas of the brain involved in appetite and reward. It is FDA-approved as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults. Candidates typically have a BMI of 30 or greater, or 27 or greater with at least one weight-related condition such as hypertension, type 2 diabetes, or high cholesterol.
What Does Naltrexone/Bupropion 8mg/90mg Treat?
Chronic weight management in adults with obesity (BMI ?30)
Chronic weight management in adults who are overweight (BMI ?27) with at least one weight-related condition
Adjunct to a reduced-calorie diet and increased physical activity
Weight-related comorbidity support (e.g., hypertension, type 2 diabetes, dyslipidemia) as part of overall weight management
Naltrexone/Bupropion 8mg/90mg Dosage
Week 1: Take 1 tablet (8mg/90mg) by mouth every morning.
Week 2: 1 tablet twice daily; Week 3: 2 tablets in the morning, 1 in the evening.
Week 4 and onward: 2 tablets twice daily (maximum 32mg/360mg per day).
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Naltrexone/Bupropion 8mg/90mg Side Effects
Common side effects
- Nausea
- Constipation
- Headache
- Vomiting
- Dizziness
- Insomnia
- Dry mouth
- Diarrhea
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Suicidal thoughts or behavior, or new/worsening depression
- Seizures
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Significant increases in blood pressure or heart rate
- Liver injury (dark urine, yellowing of skin or eyes, upper abdominal pain)
- Angle-closure glaucoma (eye pain, vision changes)
Warnings & Interactions
Boxed warning: increased risk of suicidal thoughts and behaviors in young adults taking antidepressants
Do not use with opioid medications or during opioid withdrawal; naltrexone blocks opioid effects
Contraindicated in seizure disorders, uncontrolled hypertension, and eating disorders (anorexia/bulimia)
Do not use with abrupt discontinuation of alcohol, benzodiazepines, or other sedatives
Do not take with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping one
Not for use during pregnancy; weight loss offers no benefit and may harm the fetus
Avoid other bupropion-containing products; monitor blood pressure and heart rate during treatment
Tell your prescriber about all medications, supplements, and health conditions before starting naltrexone/bupropion 8mg/90mg.
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