What is sacubitril/valsartan 24mg/26mg used for?

The 24mg/26mg strength is typically the starting dose of Entresto for adults with chronic heart failure, especially those new to the medication or with certain kidney or liver conditions. Your provider will usually increase the dose over several weeks toward a target maintenance dose.

Do I need a prescription for sacubitril/valsartan?

Yes. Sacubitril/valsartan is a prescription-only medication in the United States. A licensed healthcare provider must evaluate your condition and issue a valid prescription before this medication can be dispensed.

How does ordering and shipping work?

After you place your order and provide your prescription, a licensed provider or pharmacist reviews it for safety and accuracy. Once approved, your medication is dispensed and shipped from a licensed U.S. pharmacy to your address.

Is sacubitril/valsartan the same as Entresto?

Yes. Entresto is the brand name for sacubitril/valsartan. There is currently no FDA-approved generic version widely available in the U.S., so the brand product is typically dispensed.

Can I take sacubitril/valsartan with an ACE inhibitor?

No. Combining the two increases the risk of angioedema, a serious allergic-type swelling. You must wait at least 36 hours after your last ACE inhibitor dose before starting sacubitril/valsartan, and vice versa.

What should I avoid while taking sacubitril/valsartan?

Avoid pregnancy, potassium supplements or salt substitutes unless approved by your provider, and NSAIDs when possible. Tell your provider about all medications you take, including lithium and diuretics, and attend regular lab monitoring.

Sacubitril/Valsartan 24mg/26mg

Name: Sacubitril/Valsartan 24mg/26mg
Brand: All Family Pharmacy
SKU: sacubitril-valsartan-24mg-26mg
Availability: InStock

Generic For: Entresto

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Sacubitril/Valsartan 24mg/26mg — All Family Pharmacy

Sacubitril/valsartan 24mg/26mg is the starting-dose tablet strength of Entresto, a prescription heart failure medication that combines a neprilysin inhibitor with an angiotensin II receptor blocker. It is used to reduce the risk of cardiovascular death and heart failure hospitalization in adults with chronic heart failure. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.

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Buy Sacubitril/Valsartan 24mg/26mg (Entresto) Online

An ARNI (angiotensin receptor–neprilysin inhibitor) for chronic heart failure and reduced ejection fraction

Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge

Sacubitril/Valsartan 24mg/26mg Quick Facts

Drug class	Angiotensin receptor–neprilysin inhibitor (ARNI)
Treats	Chronic heart failure, reduced ejection fraction, pediatric heart failure
Form	Tablet
Typical dosing	Take 1 tablet by mouth twice daily.
Prescription required	Yes — prescription only

What Is Sacubitril/Valsartan 24mg/26mg?

Sacubitril/valsartan (brand name Entresto) is a combination tablet containing sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Together they help relax blood vessels, reduce strain on the heart, and lower the risk of serious heart failure events. The 24mg/26mg strength is typically the lowest starting dose, often used for patients new to the medication or with certain kidney or liver conditions. It is taken twice daily and requires a valid prescription and regular monitoring by your healthcare provider.

What Does Sacubitril/Valsartan 24mg/26mg Treat?

Chronic heart failure in adults
Heart failure with reduced ejection fraction (HFrEF)
Reducing the risk of cardiovascular death in heart failure
Reducing the risk of heart failure hospitalization
Symptomatic heart failure in pediatric patients aged 1 year and older

Sacubitril/Valsartan 24mg/26mg Dosage

Adults: Start 24mg/26mg or 49mg/51mg by mouth twice daily.
Double the dose every 2–4 weeks as tolerated.
Target maintenance: 97mg/103mg by mouth twice daily.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Sacubitril/Valsartan 24mg/26mg Side Effects

Common side effects

Low blood pressure (hypotension)
High potassium levels (hyperkalemia)
Dizziness
Cough
Kidney function changes
Fatigue

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

Angioedema (swelling of face, lips, tongue, or throat)
Severe hypotension or fainting
Acute kidney injury or worsening renal function
Severe hyperkalemia (irregular heartbeat, muscle weakness)

Warnings & Interactions

Can cause fetal harm — do not use during pregnancy
Contraindicated with any history of angioedema from ACE inhibitors or ARBs
Do not use within 36 hours of an ACE inhibitor
Contraindicated with aliskiren in patients with diabetes
Monitor blood pressure, kidney function, and potassium levels
Use caution with potassium supplements, potassium-sparing diuretics, NSAIDs, and lithium

Tell your prescriber about all medications, supplements, and health conditions before starting sacubitril/valsartan 24mg/26mg.