Sacubitril/Valsartan 49mg/51mg
Generic For: Entresto
Sacubitril/valsartan 49mg/51mg, sold under the brand name Entresto, is a combination angiotensin receptor–neprilysin inhibitor (ARNI) used to treat chronic heart failure. It helps reduce the risk of cardiovascular death and heart failure hospitalization in adults. After a licensed provider reviews your prescription, your medication ships from our licensed U.S. pharmacy.
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Buy Sacubitril/Valsartan 49mg/51mg (Entresto) Online
An angiotensin receptor–neprilysin inhibitor (ARNI) for chronic heart failure and heart failure with reduced ejection fraction
Sacubitril/Valsartan 49mg/51mg Quick Facts
| Drug class | Angiotensin receptor–neprilysin inhibitor |
|---|---|
| Treats | Chronic heart failure, reduced ejection fraction heart failure, pediatric heart failure |
| Form | Tablet |
| Typical dosing | Take 1 tablet by mouth twice daily. |
| Prescription required | Yes — prescription only |
What Is Sacubitril/Valsartan 49mg/51mg?
Sacubitril/valsartan is a prescription tablet that combines two medicines: sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Together they help relax blood vessels, reduce strain on the heart, and support the body's natural systems that manage fluid and sodium balance. It is FDA-approved to lower the risk of cardiovascular death and hospitalization in adults with chronic heart failure, with benefits most clearly shown in patients with reduced ejection fraction. The 49mg/51mg strength is a commonly prescribed twice-daily dose that is often titrated toward a target maintenance dose.
What Does Sacubitril/Valsartan 49mg/51mg Treat?
Chronic heart failure in adults
Heart failure with reduced ejection fraction (HFrEF)
Reduction of cardiovascular death risk in heart failure
Reduction of heart failure hospitalization risk
Symptomatic heart failure in pediatric patients aged 1 year and older
Sacubitril/Valsartan 49mg/51mg Dosage
Take 1 tablet (49mg/51mg) by mouth twice daily.
Double the dose after 2–4 weeks as tolerated to the target of 97mg/103mg twice daily.
Use as directed by your prescriber; dosing may differ based on prior ACE inhibitor/ARB use, kidney or liver function.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Sacubitril/Valsartan 49mg/51mg Side Effects
Common side effects
- Low blood pressure (hypotension)
- High potassium levels (hyperkalemia)
- Cough
- Dizziness
- Kidney function changes
- Fatigue
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Angioedema (swelling of face, lips, tongue, or throat)
- Severe hypotension (fainting, severe dizziness)
- Acute kidney injury or worsening renal function
- Severe hyperkalemia (irregular heartbeat, muscle weakness)
- Signs of fetal harm during pregnancy
Warnings & Interactions
Boxed warning: can cause fetal harm; stop immediately if pregnancy is detected
Do not use within 36 hours of an ACE inhibitor
Contraindicated with a history of angioedema from ACE inhibitors or ARBs
Contraindicated with aliskiren in patients with diabetes
Monitor blood pressure, potassium, and kidney function
Use caution with potassium-sparing diuretics, potassium supplements, NSAIDs, and lithium
Not recommended in severe hepatic impairment
Tell your prescriber about all medications, supplements, and health conditions before starting sacubitril/valsartan 49mg/51mg.
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