Sacubitril/Valsartan 97mg/103mg
Generic For: Entresto
Sacubitril/valsartan 97mg/103mg (brand name Entresto) is a combination heart failure medication that helps reduce the risk of cardiovascular death and heart failure hospitalization in adults with chronic heart failure. It combines a neprilysin inhibitor with an angiotensin II receptor blocker. After review of your prescription by a licensed provider, your order ships from a licensed U.S. pharmacy.
Compare all Sacubitril/Valsartan options →
Select Quantity *
30-day supply · $1.25/tablet
How It Works
- Select your medication
- Licensed providers review & prescribe
- Our licensed U.S. pharmacists fill your prescription
- Delivered to you as soon as the next day
Price: $75.00
HSA/FSA Eligible*Doctor visit fee & delivery cost not included in price. Refills at provider discretion.
Pharmacist Support
Fast Shipping
Licensed U.S. Pharmacy
Buy Sacubitril/Valsartan 97mg/103mg (Entresto) Online
An angiotensin receptor–neprilysin inhibitor (ARNI) for chronic heart failure and reduced ejection fraction
Sacubitril/Valsartan 97mg/103mg Quick Facts
| Drug class | Angiotensin receptor–neprilysin inhibitor (ARNI) |
|---|---|
| Treats | Chronic heart failure, reduced ejection fraction, pediatric heart failure |
| Form | Tablet |
| Typical dosing | Take 1 tablet by mouth twice daily. |
| Prescription required | Yes — prescription only |
What Is Sacubitril/Valsartan 97mg/103mg?
Sacubitril/valsartan is a prescription tablet that combines two medicines: sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Together they relax blood vessels, reduce strain on the heart, and help the body eliminate excess fluid and sodium. It is FDA-approved to lower the risk of cardiovascular death and hospitalization in adults with chronic heart failure, with benefits most clearly seen in patients whose ejection fraction is below normal. The 97mg/103mg strength is the standard maintenance (target) dose for most adults.
What Does Sacubitril/Valsartan 97mg/103mg Treat?
Chronic heart failure in adults (reduced risk of cardiovascular death and hospitalization)
Heart failure with reduced ejection fraction (HFrEF)
Heart failure with below-normal ejection fraction
Symptomatic heart failure in pediatric patients aged 1 year and older (other strengths/forms may be used)
Sacubitril/Valsartan 97mg/103mg Dosage
Take 1 tablet (97mg/103mg) by mouth twice daily as the maintenance target dose.
Treatment is typically started at a lower strength and doubled every 2–4 weeks as tolerated to reach this dose.
Use ongoing as directed by your prescriber.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Sacubitril/Valsartan 97mg/103mg Side Effects
Common side effects
- Low blood pressure (hypotension)
- High potassium levels (hyperkalemia)
- Cough
- Dizziness
- Kidney function changes
- Fatigue
- Lightheadedness when standing
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Angioedema (swelling of face, lips, tongue, or throat)
- Symptomatic hypotension (fainting, severe dizziness)
- Worsening kidney function or kidney failure
- Severe hyperkalemia (irregular heartbeat, muscle weakness)
- Signs of fetal harm if taken during pregnancy
Warnings & Interactions
Do not take with an ACE inhibitor; allow 36 hours between switching
Contraindicated with a history of angioedema related to ACE inhibitor or ARB therapy
Can cause fetal harm — do not use during pregnancy
Do not combine with aliskiren in patients with diabetes
Monitor blood pressure, kidney function, and potassium levels
Use caution with potassium supplements, potassium-sparing diuretics, NSAIDs, and lithium
Tell your prescriber about all medications, supplements, and health conditions before starting sacubitril/valsartan 97mg/103mg.
Talk to U.S.-Based Support
Our licensed pharmacy team in Boca Raton, Florida — real people, no overseas call centers.