Yeast Infection
Commonly treated with Fluconazole & Terconazole
A yeast infection is a common fungal infection, most often caused by an overgrowth of Candida in the vagina, that leads to itching, irritation, and discharge. Prescription yeast infection medicine, including oral fluconazole and vaginal antifungal creams, is available online after a licensed provider reviews your health information.
Select Your Treatments *
How It Works
- Select your medication
- Licensed providers review & prescribe
- Our licensed U.S. pharmacists fill your prescription
- Delivered to you as soon as the next day
Your selection (1): $0.00
HSA/FSA Eligible*Doctor visit fee & delivery cost not included in price. Refills at provider discretion.
Order Yeast Infection Treatment Online
Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge — Last updated July 15, 2026
Choosing and Using Your Treatment
| Treatment | Choose this if… | How to Take |
|---|---|---|
| Fluconazole 150mg | You prefer a convenient one-time oral pill for an uncomplicated vaginal yeast infection. | Take 1 tablet by mouth as a single dose. |
| Terconazole 0.4% Vaginal Cream | You prefer a vaginal cream applied over 7 nights, or oral treatment is not a good fit for you. | Insert 1 applicatorful (5 g) vaginally once daily at bedtime for 7 days. |
| Terconazole 0.8% Vaginal Cream | You want a shorter 3-night vaginal cream course. | Insert 1 applicatorful (5 g) vaginally once daily at bedtime for 3 days. |
| Clotrimazole 1% Cream | You have external vulvar irritation or a male (penile) yeast infection needing a topical antifungal. Often used alongside oral fluconazole to relieve external itching while the oral dose clears the infection. | Apply a thin layer topically to the affected area twice daily for 7 days. |
About Yeast Infection (Vaginal Yeast Infection (Vaginal Candidiasis))
A yeast infection happens when Candida, a fungus that normally lives on the skin and in the vagina in small amounts, grows out of balance. Vaginal yeast infections are extremely common — most women experience at least one in their lifetime, and some have repeat episodes. Typical symptoms include intense itching, burning, redness, and a thick white discharge that often looks like cottage cheese. Yeast infections can also affect men, usually as redness and itching on the head of the penis, and can occur in the mouth or skin folds. Antibiotic use, hormonal changes, uncontrolled diabetes, and a weakened immune system all make yeast overgrowth more likely. Most uncomplicated infections respond well to a short course of antifungal treatment, taken by mouth or applied vaginally.
Signs & symptoms
- Vaginal itching, burning, or irritation
- Thick, white, odorless yeast infection discharge that looks like cottage cheese
- Redness and swelling of the vulva or vaginal opening
- Burning during urination or during sex
- Soreness or a rash in the affected area
- In men: redness, itching, or small bumps on the head of the penis
Causes & risk factors
- Overgrowth of Candida, the yeast that normally lives in the vagina
- Recent antibiotic use, which disrupts protective bacteria
- Hormonal changes from pregnancy, birth control, or the menstrual cycle
- Uncontrolled diabetes or high blood sugar
- A weakened immune system
- Moisture and heat from tight, non-breathable clothing or wet swimwear
- Sexual activity can sometimes pass yeast between partners, though it is not classified as an STI
Prevention
- Wear breathable cotton underwear and avoid tight, non-breathable clothing
- Change out of wet swimsuits and sweaty workout clothes promptly
- Avoid douching and scented feminine sprays or washes
- Wipe front to back after using the bathroom
- Only take antibiotics when prescribed and needed
- Keep blood sugar well controlled if you have diabetes
- Avoid very hot baths and prolonged time in hot tubs
When to see a doctor
Online treatment is a good fit if you have classic symptoms of an uncomplicated yeast infection — itching, irritation, and thick white discharge — especially if you have had a diagnosed yeast infection before and recognize the symptoms. See a provider in person if this is your first episode, if symptoms do not improve after a full course of treatment, if you have 4 or more infections in a year, if you are pregnant, or if you have fever, pelvic pain, foul-smelling or discolored discharge, or sores — these can signal a different infection that needs an exam and testing. Seek urgent care for high fever with pelvic or abdominal pain.
Oral vs. Vaginal Yeast Infection Treatments
Both oral and vaginal antifungal medicines are considered effective for uncomplicated yeast infections. The best choice usually comes down to preference, medical history, and whether you are pregnant (vaginal treatments are generally preferred in pregnancy — a provider will advise).
| Option | How it's used | Typical course |
|---|---|---|
| Fluconazole (oral) | Single tablet taken by mouth | One dose; a second dose may be prescribed for more severe cases |
| Terconazole (vaginal cream) | Inserted vaginally at bedtime | 3 nights (0.8%) or 7 nights (0.4%) |
| Clotrimazole (topical cream) | Applied to external skin | About 7 days for external or penile symptoms |
When It Might Not Be a Yeast Infection
Several conditions can mimic yeast infection symptoms, and using antifungal medicine for the wrong problem can delay proper care. Consider an in-person evaluation if your symptoms include:
- Gray or thin discharge with a fishy odor — more typical of bacterial vaginosis
- Green or frothy discharge — can indicate trichomoniasis
- Sores, blisters, or unusual bleeding — needs an exam to rule out other infections
- Symptoms that keep returning — 4 or more infections a year (recurrent candidiasis) may need testing and a longer treatment plan
Studies show many people who self-diagnose a yeast infection actually have a different condition — when in doubt, get evaluated.
Sources & References
Frequently Asked Questions
What is a yeast infection?
A yeast infection is a fungal infection caused by overgrowth of Candida, a yeast that naturally lives on the body in small amounts. The most common type is a vaginal yeast infection, which causes itching, burning, and thick white discharge. Yeast infections can also affect the penis, mouth, and skin folds.
What causes a yeast infection?
Yeast infections occur when something disrupts the normal balance of bacteria and yeast in the vagina. Common triggers include antibiotics, hormonal changes from pregnancy or birth control, uncontrolled diabetes, a weakened immune system, and trapped moisture from tight or wet clothing.
What does a yeast infection look like?
A vaginal yeast infection typically causes redness and swelling of the vulva along with a thick, white, clumpy discharge often compared to cottage cheese. The discharge usually has little or no odor. In men, a yeast infection often appears as red, itchy skin or small bumps on the head of the penis.
How to get rid of a yeast infection in 24 hours?
There is no guaranteed way to clear a yeast infection within 24 hours. A single dose of prescription oral fluconazole is one of the fastest treatment options, but symptoms typically take one to several days to improve as the medication works. If symptoms persist after treatment, contact a healthcare provider.
How long does a yeast infection last?
With antifungal treatment, most mild to moderate yeast infections improve within a few days and resolve within about a week. Without treatment, symptoms may linger or worsen. If symptoms have not improved after finishing a full course of treatment, follow up with a provider.
How often can you take fluconazole for yeast infection?
For an uncomplicated vaginal yeast infection, fluconazole is usually prescribed as a single one-time dose. For more severe or recurrent infections, a provider may prescribe additional doses spaced days apart or a longer preventive schedule. Always follow the specific instructions from your prescriber rather than repeating doses on your own.
What does a yeast infection feel like?
Most people describe intense itching and burning in and around the vagina, sometimes with soreness, swelling, and discomfort during urination or sex. Symptoms can range from mildly annoying to significantly uncomfortable. Men with a penile yeast infection typically notice itching, redness, and irritation.
Can men get yeast infections?
Yes. A male yeast infection most often affects the head of the penis, causing redness, itching, irritation, and sometimes a rash or white patches. It is more common in men who are uncircumcised, have diabetes, or whose partner has a vaginal yeast infection, and it is usually treated with a topical antifungal cream.
Treatments for Yeast Infection
Find out more information about each treatment.