Acyclovir 5% Ointment
Generic For: Zovirax Cream
Acyclovir 5% Ointment (brand name Zovirax) is a prescription topical antiviral used to treat herpes simplex virus infections, including initial genital herpes outbreaks and cold sores. Applied directly to affected skin, it can help lesions heal and reduce discomfort. Order online and, after review by a licensed provider, your medication ships from a licensed U.S. pharmacy.
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7-day supply · $0.83/gram
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Buy Acyclovir 5% Ointment Online
An antiviral ointment for cold sores, genital herpes, and herpes simplex skin infections
Acyclovir 5% Ointment Quick Facts
| Drug class | Topical antiviral |
|---|---|
| Treats | Genital herpes, cold sores, herpes simplex skin infections |
| Form | Ointment |
| Typical dosing | Apply a small amount to the cold sore topically 5 times per day for 4 days. |
| Prescription required | Yes — prescription only |
What Is Acyclovir 5% Ointment?
Acyclovir 5% Ointment is a topical antiviral medication that treats infections caused by the herpes simplex virus (HSV). It works by interfering with the virus's ability to copy itself, which can help sores heal and ease pain or itching. The ointment is applied directly to affected skin several times a day at the first sign of an outbreak. It manages symptoms but does not cure herpes or prevent spreading the virus to others.
What Does Acyclovir 5% Ointment Treat?
Cold sores (herpes labialis)
Initial episodes of genital herpes
Limited mucocutaneous herpes simplex (HSV) infections in immunocompromised patients
Herpes simplex skin and mucous membrane lesions
Acyclovir 5% Ointment Dosage
Apply topically to affected areas every 3 hours, 6 times daily, for 7 days.
Use approximately a 0.5-inch ribbon of ointment per 4 square inches of surface area.
Begin as early as possible after signs or symptoms appear.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Acyclovir 5% Ointment Side Effects
Common side effects
- Mild pain or burning at the application site
- Stinging where applied
- Itching
- Skin rash
- Dry or flaky skin
- Mild skin irritation
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Signs of allergic reaction (hives, swelling of face, lips, or tongue)
- Difficulty breathing
- Severe skin irritation, blistering, or peeling at the application site
- Worsening or spreading of lesions despite treatment
Warnings & Interactions
For external, cutaneous use only — do not use in the eyes, mouth, or vagina
Do not use if allergic to acyclovir or valacyclovir
Apply with a finger cot or rubber glove to avoid spreading infection
Does not cure herpes or prevent transmission to others
Avoid sexual contact while genital lesions are present
Not intended to prevent recurrent HSV outbreaks
Tell your provider if you are pregnant, breastfeeding, or immunocompromised
Tell your prescriber about all medications, supplements, and health conditions before starting acyclovir 5% ointment.
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