Carbidopa Levodopa 25-250mg

Generic For: Sinemet

Carbidopa levodopa 25-250mg (brand name Sinemet) is a combination tablet used to treat the symptoms of Parkinson's disease and certain forms of parkinsonism, including tremor, stiffness, and slowed movement. Levodopa converts to dopamine in the brain, while carbidopa helps more levodopa reach the brain and reduces nausea. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.

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Buy Carbidopa Levodopa 25-250mg Online

A dopamine precursor combination medication for Parkinson's disease and parkinsonism symptoms

Carbidopa Levodopa 25-250mg Quick Facts

Drug classDopamine precursor combination
TreatsParkinson's disease, post-encephalitic parkinsonism, symptomatic parkinsonism
FormTablet
Typical dosingTake as directed by Primary Physician by mouth.
Prescription requiredYes — prescription only

What Is Carbidopa Levodopa 25-250mg?

Carbidopa levodopa 25-250mg is a prescription tablet that combines two medicines to manage the symptoms of Parkinson's disease. Levodopa is converted into dopamine, a chemical messenger that is deficient in the brains of people with Parkinson's. Carbidopa prevents levodopa from breaking down before it reaches the brain, which allows lower levodopa doses and helps reduce nausea and vomiting. It is sold under the brand name Sinemet and is taken by mouth, usually several times a day as directed by your provider.

What Does Carbidopa Levodopa 25-250mg Treat?

Parkinson's disease
Post-encephalitic parkinsonism
Parkinsonism following carbon monoxide intoxication
Parkinsonism following manganese intoxication
Symptomatic parkinsonism (as directed by a provider)

Carbidopa Levodopa 25-250mg Dosage

Take 1 tablet (25-250mg) by mouth 3 to 4 times daily, as directed.
Dosage is individualized and titrated by your provider based on response.
Do not exceed 8 tablets (200mg carbidopa / 2,000mg levodopa) per day.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Carbidopa Levodopa 25-250mg Side Effects

Common side effects

  • Nausea
  • Dizziness
  • Headache
  • Drowsiness or sleepiness
  • Dry mouth
  • Loss of appetite
  • Involuntary movements (dyskinesia)
  • Trouble sleeping

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

  • Sudden sleep episodes during daily activities
  • Hallucinations or confusion
  • Severe or worsening involuntary movements
  • Depression or suicidal thoughts
  • Symptoms of neuroleptic malignant-like syndrome with abrupt stopping (high fever, muscle rigidity)
  • Orthostatic hypotension (fainting or severe lightheadedness)

Warnings & Interactions

Do not use with nonselective MAO inhibitors or within 14 days of stopping them
Do not stop abruptly; sudden withdrawal may cause a serious fever and rigidity reaction
May cause sudden sleep onset; use caution driving until you know how it affects you
Can cause or worsen hallucinations, confusion, and impulse-control problems
Use caution with narrow-angle glaucoma; contraindicated in untreated narrow-angle glaucoma
High-protein meals and iron supplements may reduce absorption; separate timing
Use caution with a history of melanoma, heart disease, or peptic ulcer

Tell your prescriber about all medications, supplements, and health conditions before starting carbidopa levodopa 25-250mg.

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Frequently Asked Questions

Do I need a prescription for carbidopa levodopa 25-250mg?

Yes. Carbidopa levodopa is a prescription-only medication in the United States. A licensed provider must review and approve your prescription before our pharmacy can dispense it.

What is carbidopa levodopa 25-250mg used for?

It treats the symptoms of Parkinson's disease and certain types of parkinsonism, such as those following encephalitis or carbon monoxide or manganese exposure. It helps improve movement symptoms like tremor, stiffness, and slowness, but it does not cure the underlying condition.

What is the difference between carbidopa levodopa 25-250 and other strengths?

The 25-250 tablet contains 25mg of carbidopa and 250mg of levodopa. Other strengths, such as 25-100 and 10-100, contain different amounts, and your provider chooses the strength that fits your individualized dose.

How should I take carbidopa levodopa 25-250mg?

Most adults take one tablet by mouth three to four times daily, exactly as prescribed. High-protein meals and iron supplements can reduce absorption, so ask your provider or pharmacist about the best timing around food.

Can I stop taking carbidopa levodopa suddenly?

No. Stopping abruptly can cause a serious reaction involving high fever and muscle rigidity. Always talk to your provider before changing your dose or discontinuing this medication.

How does ordering and shipping work?

After you place your order, a licensed provider reviews your prescription. Once approved, your medication is filled and shipped directly to you from our licensed U.S. pharmacy in discreet packaging.

Is Sinemet the same as carbidopa levodopa?

Yes. Sinemet is the brand name for carbidopa levodopa, and generic versions contain the same active ingredients in the same strengths. Ask your pharmacist if you have questions about switching between brand and generic.