Nitrofurantoin 100mg (Mono/Macro)

Generic For: Macrobid

Nitrofurantoin mono/macro 100mg (brand name Macrobid) is a nitrofuran antibiotic used to treat acute uncomplicated urinary tract infections (bladder infections) caused by susceptible bacteria. If a licensed provider determines it is appropriate for you after review, your prescription ships from a licensed U.S. pharmacy.

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Buy Nitrofurantoin Mono/Macro 100mg (Macrobid) Online

Nitrofuran antibiotic for urinary tract infections (UTIs) and acute bladder infections (cystitis)

Nitrofurantoin 100mg (Mono/Macro) Quick Facts

Drug classNitrofuran antibiotic
TreatsUrinary tract infections (UTIs), acute bladder infections (cystitis)
FormCapsule
Typical dosingTake 1 capsule by mouth twice a day for 10 days.
Prescription requiredYes — prescription only

What Is Nitrofurantoin 100mg (Mono/Macro)?

Nitrofurantoin mono/macro is an oral antibiotic that combines nitrofurantoin monohydrate and macrocrystals in a single capsule, sold under the brand name Macrobid. It works by concentrating in the urine, where it damages bacterial proteins and DNA to stop the growth of bacteria that cause urinary tract infections. It is FDA-approved specifically for acute uncomplicated urinary tract infections (acute cystitis) and is not intended for kidney infections or infections outside the urinary tract. A prescription from a licensed provider is required.

What Does Nitrofurantoin 100mg (Mono/Macro) Treat?

Acute uncomplicated urinary tract infections (UTIs)
Acute bladder infections (cystitis)
UTIs caused by susceptible Escherichia coli strains
UTIs caused by susceptible Staphylococcus saprophyticus strains

Nitrofurantoin 100mg (Mono/Macro) Dosage

Adults: 100 mg by mouth every 12 hours for 7 days.
Take with food to improve absorption and tolerability.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Nitrofurantoin 100mg (Mono/Macro) Side Effects

Common side effects

  • Nausea
  • Headache
  • Gas (flatulence)
  • Diarrhea
  • Dizziness
  • Abdominal pain
  • Harmless brown or dark yellow discoloration of urine

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

  • Acute or chronic pulmonary reactions (cough, shortness of breath, fever)
  • Liver injury (jaundice, dark urine, hepatitis symptoms)
  • Peripheral neuropathy (numbness or tingling in hands or feet)
  • Hemolytic anemia (unusual fatigue, pale skin), especially with G6PD deficiency
  • Severe or persistent diarrhea (possible C. difficile infection)
  • Severe allergic or skin reactions

Warnings & Interactions

Do not use with significantly reduced kidney function (contraindicated per labeling)
Contraindicated in pregnancy at term (38–42 weeks), during labor, or when delivery is imminent
Contraindicated in infants under 1 month of age
Do not use if you had prior liver or lung reactions to nitrofurantoin
Use with caution in G6PD deficiency due to hemolytic anemia risk
Magnesium trisilicate antacids can reduce absorption; avoid taking together
Not effective for kidney infections (pyelonephritis) or perinephric abscesses

Tell your prescriber about all medications, supplements, and health conditions before starting nitrofurantoin 100mg (mono/macro).

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Frequently Asked Questions

What is nitrofurantoin mono/macro used for?

Nitrofurantoin mono/macro (Macrobid) is FDA-approved to treat acute uncomplicated urinary tract infections, commonly called bladder infections. It works against susceptible bacteria such as E. coli and Staphylococcus saprophyticus. It is not used for kidney infections or infections outside the urinary tract.

Do I need a prescription for nitrofurantoin mono/macro?

Yes, nitrofurantoin is a prescription-only medication in the United States. A licensed healthcare provider must evaluate your symptoms and confirm the medication is appropriate before it can be dispensed.

How does ordering and shipping work?

After you complete a health questionnaire, a licensed provider reviews your information to determine whether nitrofurantoin is appropriate. If approved, your prescription is filled and shipped from a licensed U.S. pharmacy in discreet packaging.

What is the difference between nitrofurantoin mono/macro and Macrobid?

They are the same medication — Macrobid is the brand name, and nitrofurantoin monohydrate/macrocrystals is the generic. Both contain the same active ingredient in a 100mg twice-daily capsule.

How should I take nitrofurantoin mono/macro 100mg?

The standard adult dose is one 100mg capsule by mouth every 12 hours for 7 days, taken with food. Complete the full course even if you feel better sooner, and contact your provider if symptoms do not improve.

Can I take nitrofurantoin while pregnant?

Nitrofurantoin is contraindicated at term (38–42 weeks of pregnancy), during labor, or when delivery is imminent because of the risk of hemolytic anemia in the newborn. Talk to your provider about whether it is appropriate earlier in pregnancy.

Why is my urine dark after taking nitrofurantoin?

Nitrofurantoin can turn urine brown or dark yellow, which is a harmless and expected effect of the medication. The color returns to normal after you finish the course; contact your provider if you also have symptoms like jaundice or unusual fatigue.