Can you get penicillin or amoxicillin over the counter?

No. In the United States, both penicillin and amoxicillin are prescription-only antibiotics and cannot be purchased over the counter. A licensed healthcare provider must evaluate your condition and issue a prescription before either medication can be dispensed.

Do I need a prescription to buy Penicillin 500mg?

Yes, Penicillin 500mg (Pen-Vee K) requires a valid prescription. If you don't already have one, a licensed provider can review your health information through our platform and, if appropriate, issue a prescription.

How does ordering and shipping work?

After you place your order, a licensed U.S. provider reviews your health information or existing prescription. Once approved, your medication is dispensed by a licensed U.S. pharmacy and shipped directly to your address in discreet packaging.

What is Penicillin 500mg used for?

It is used to treat bacterial infections such as strep throat, mild skin infections, and certain mild respiratory infections. It is also prescribed to prevent recurrent rheumatic fever in people with a history of the condition.

What's the difference between penicillin and amoxicillin?

Both are penicillin-class antibiotics, but amoxicillin covers a somewhat broader range of bacteria and is often dosed less frequently. Your provider will choose the antibiotic best suited to your specific infection.

How long does it take Penicillin 500mg to work?

Many people begin to feel better within a few days of starting treatment. However, it's important to finish the entire prescribed course — typically 10 days for strep throat — to fully clear the infection and reduce the risk of complications.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it's almost time for your next dose. Do not take two doses at once; simply continue your regular schedule and contact your pharmacist with any questions.

Penicillin 500mg

Name: Penicillin 500mg
Brand: All Family Pharmacy
SKU: penicillin-500mg
Availability: InStock

Generic For: Pen-Vee K

4.8 Google Star Rated · 200,000+ Orders Shipped

Penicillin 500mg (Pen-Vee K, penicillin V potassium) is a prescription antibiotic used to treat bacterial infections such as strep throat, mild skin infections, and certain respiratory infections. While many people search for penicillin or amoxicillin over the counter, both require a prescription in the U.S. After a licensed provider reviews your order, your medication ships from a licensed U.S. pharmacy.

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Buy Penicillin 500mg (Pen-Vee K) Online

A penicillin antibiotic for strep throat, skin infections, and mild respiratory tract infections

Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge

Penicillin 500mg Quick Facts

Drug class	Penicillin antibiotic
Treats	Strep throat, skin infections, respiratory tract infections, rheumatic fever prevention
Form	Tablet
Typical dosing	Take 1 tablet by mouth 4 times daily for 10 days.
Prescription required	Yes — prescription only

What Is Penicillin 500mg?

Penicillin 500mg (brand name Pen-Vee K) is an oral tablet containing penicillin V potassium, one of the original penicillin-class antibiotics. It works by stopping the growth of susceptible bacteria, which allows your body to clear the infection. It is commonly prescribed for streptococcal infections such as strep throat, as well as certain skin and respiratory infections. Penicillin is not available over the counter in the U.S. — a prescription from a licensed provider is required.

What Does Penicillin 500mg Treat?

Strep throat (streptococcal pharyngitis)
Mild-to-moderate skin and soft-tissue infections
Mild pneumococcal respiratory tract infections
Prevention of recurrent rheumatic fever
Fusospirochetosis (Vincent's infection) of the mouth and gums
Scarlet fever

Penicillin 500mg Dosage

Strep throat: 500 mg by mouth every 12 hours for 10 days
Pneumococcal respiratory infections: 250–500 mg by mouth every 6 hours until afebrile for at least 2 days
Rheumatic fever prophylaxis: 250 mg by mouth twice daily

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Penicillin 500mg Side Effects

Common side effects

Nausea
Vomiting
Diarrhea
Stomach upset
Black hairy tongue
Headache
Oral or vaginal thrush

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

Severe allergic reaction (hives, swelling, difficulty breathing)
Severe or persistent watery/bloody diarrhea (C. difficile colitis)
Severe skin rash or blistering
Unusual bleeding or bruising
Seizures (rare, with high doses or kidney impairment)

Warnings & Interactions

Do not use if allergic to penicillin or cephalosporin antibiotics
Serious, occasionally fatal anaphylactic reactions have occurred
May cause C. difficile-associated diarrhea, even weeks after treatment
Complete the full prescribed course even if you feel better
May reduce the effectiveness of oral contraceptives
Probenecid increases penicillin blood levels
Tell your provider about kidney problems before use

Tell your prescriber about all medications, supplements, and health conditions before starting penicillin 500mg.