Rifampin 300mg
Generic For: Rifadin
Rifampin 300mg (brand name Rifadin) is a rifamycin antibiotic capsule prescribed as part of combination therapy for tuberculosis and to eliminate Neisseria meningitidis from the noses and throats of asymptomatic carriers. After a licensed provider reviews your prescription, your rifampin order ships from a licensed U.S. pharmacy.
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14-day supply · $1.43/capsule
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Rifampin (Rifadin) is a rifamycin antibiotic used to treat tuberculosis and to eliminate meningococcal bacteria in carriers.
Rifampin 300mg Quick Facts
| Drug class | Rifamycin antibiotic |
|---|---|
| Treats | Tuberculosis (TB), meningococcal carrier state |
| Form | Capsule |
| Typical dosing | Take 1 capsule by mouth every 12 hours on an empty stomach with a full glass of water. |
| Prescription required | Yes — prescription only |
What Is Rifampin 300mg?
Rifampin is a prescription antibiotic in the rifamycin class, sold under the brand name Rifadin. It works by blocking an enzyme bacteria need to make RNA, which stops bacterial growth. Rifampin is most commonly used with other medicines to treat all forms of tuberculosis (TB). It is also used short-term to eliminate meningococcal bacteria from people who carry them without symptoms, helping prevent spread to others.
What Does Rifampin 300mg Treat?
Pulmonary tuberculosis (in combination with other anti-TB drugs)
Extrapulmonary tuberculosis (in combination therapy)
Latent tuberculosis infection (as directed by a provider)
Asymptomatic Neisseria meningitidis carriers (to eliminate carriage)
Rifampin 300mg Dosage
Tuberculosis: 10 mg/kg (up to 600 mg) by mouth once daily, as part of combination therapy.
Meningococcal carriers: 600 mg by mouth twice daily for 2 days.
Take on an empty stomach, 1 hour before or 2 hours after a meal.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Rifampin 300mg Side Effects
Common side effects
- Reddish-orange discoloration of urine, sweat, tears, and saliva
- Nausea
- Vomiting
- Heartburn
- Headache
- Drowsiness or fatigue
- Dizziness
- Rash or itching
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Signs of liver injury (yellowing of skin/eyes, dark urine, severe fatigue)
- Severe skin reactions (blistering, peeling rash)
- Flu-like syndrome with fever, chills, or muscle aches
- Unusual bleeding or bruising (low platelets)
- Severe or persistent diarrhea (possible C. difficile infection)
- Signs of severe allergic reaction (swelling, trouble breathing)
Warnings & Interactions
Can cause serious liver injury; liver function monitoring may be required
Do not use with certain HIV protease inhibitors (e.g., atazanavir, ritonavir-boosted regimens)
Strong enzyme inducer — reduces effectiveness of many drugs, including hormonal contraceptives, warfarin, and some antifungals
Contraindicated with hypersensitivity to rifampin or other rifamycins
May permanently stain soft contact lenses orange-red
Intermittent or interrupted dosing increases risk of flu-like reactions and serious immune effects
Tell your provider about all medications and supplements before starting
Tell your prescriber about all medications, supplements, and health conditions before starting rifampin 300mg.
Sources & References
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