Can I take cyclobenzaprine and trazodone together?

Cyclobenzaprine and trazodone can both cause sedation and both affect serotonin, so combining them may increase drowsiness and, rarely, the risk of serotonin syndrome. Some providers do prescribe them together with monitoring, but you should never combine them on your own. Always tell your provider about every medication you take.

Is it safe to take trazodone and fluoxetine together?

Trazodone and fluoxetine both increase serotonin activity, and fluoxetine can also raise trazodone levels in the blood. Providers sometimes prescribe this combination at adjusted doses, but it requires monitoring for serotonin syndrome and excess sedation. Do not combine these medications without your provider's direction.

Do I need a prescription for Trazodone 100mg?

Yes. Trazodone is a prescription-only medication in the United States. A licensed provider must review your health information and approve a prescription before we can dispense it.

How does ordering and shipping work?

After you place your order, a licensed provider reviews your health information or your existing prescription. Once approved, your medication is dispensed by a licensed U.S. pharmacy and shipped to your address in discreet packaging.

What is trazodone used for?

Trazodone is FDA-approved to treat major depressive disorder. Because it is sedating, providers sometimes also prescribe it off-label for insomnia. Your provider will determine whether it is appropriate for your situation.

How should I take Trazodone 100mg tablets?

Take trazodone exactly as prescribed, shortly after a meal or a light snack to improve absorption and reduce dizziness. Do not stop suddenly without talking to your provider, as gradual dose reduction is usually recommended.

Can I drink alcohol while taking trazodone?

No. Alcohol can significantly increase trazodone's sedative effects and impair judgment and coordination. Avoid alcohol while taking this medication.

Trazodone 100mg

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Trazodone 100mg (brand name Desyrel) is a prescription serotonin modulator antidepressant approved by the FDA to treat major depressive disorder. Many patients also ask about combining medications — such as trazodone and fluoxetine, or cyclobenzaprine and trazodone — which is why every order is reviewed by a licensed provider first. After provider review and approval, your medication ships directly from a licensed U.S. pharmacy.

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Buy Trazodone 100mg (Desyrel) Online

A serotonin modulator antidepressant used for major depressive disorder, including depression with anxiety or sleep disturbance

Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge

Trazodone 100mg Quick Facts

Drug class	Serotonin modulator antidepressant
Treats	Major depressive disorder, depression with anxiety symptoms, depression-related insomnia
Form	Tablet
Typical dosing	Take 1 tablet by mouth daily.
Prescription required	Yes — prescription only

What Is Trazodone 100mg?

Trazodone is a prescription antidepressant in the serotonin modulator class, sold under the brand name Desyrel. It works by affecting serotonin activity in the brain, which can help improve mood over time. It is FDA-approved for major depressive disorder and is sometimes chosen when depression is accompanied by anxiety or trouble sleeping. Because trazodone can interact with other medicines — a common concern for people searching about trazodone and fluoxetine or cyclobenzaprine and trazodone — it should only be used under the care of a licensed provider.

What Does Trazodone 100mg Treat?

Major depressive disorder (MDD)
Depression with symptoms of anxiety
Depression accompanied by sleep disturbance
Off-label use for insomnia (only as directed by a provider)

Trazodone 100mg Dosage

Initial: 150 mg by mouth daily in divided doses, taken shortly after a meal or snack.
May increase by 50 mg/day every 3–4 days as directed by your provider.
Maximum: 400 mg/day (outpatient); 600 mg/day (inpatient).

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Trazodone 100mg Side Effects

Common side effects

Drowsiness or sedation
Dizziness or lightheadedness
Dry mouth
Headache
Nausea or vomiting
Blurred vision
Fatigue
Constipation

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

Serotonin syndrome (agitation, rapid heartbeat, fever, muscle rigidity)
Priapism (painful, prolonged erection) — seek emergency care
Irregular heartbeat or QT prolongation
Suicidal thoughts or behavior, especially in young adults
Severe low blood pressure or fainting
Unusual bleeding or bruising

Warnings & Interactions

Boxed warning: increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults
Do not use with or within 14 days of MAO inhibitors
Risk of serotonin syndrome when combined with other serotonergic drugs (e.g., SSRIs such as fluoxetine)
Additive sedation with CNS depressants, including muscle relaxants like cyclobenzaprine, alcohol, and opioids
May cause orthostatic hypotension — rise slowly from sitting or lying down
Use caution with drugs that prolong the QT interval or in patients with cardiac disease
Avoid driving or operating machinery until you know how trazodone affects you

Tell your prescriber about all medications, supplements, and health conditions before starting trazodone 100mg.