Valacyclovir 500mg

Generic For: Valtrex

Valacyclovir 500mg (brand name Valtrex) is a prescription antiviral tablet used to treat infections caused by herpes viruses, including cold sores, genital herpes, and shingles. After a licensed provider reviews your information and issues a prescription, your valacyclovir order ships from a licensed U.S. pharmacy.

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5-day supply · $2.50/tablet

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  2. Licensed providers review & prescribe
  3. Our licensed U.S. pharmacists fill your prescription
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Buy Valacyclovir 500mg Online

An antiviral medication for cold sores, genital herpes, and shingles

Valacyclovir 500mg Quick Facts

Drug classAntiviral (nucleoside analogue)
TreatsCold sores, genital herpes, shingles
FormTablet
Typical dosingTake 2 tablets by mouth daily for 2-5 days.
Prescription requiredYes — prescription only

What Is Valacyclovir 500mg?

Valacyclovir is a prescription antiviral medication and the generic form of Valtrex. Once absorbed, it converts to acyclovir, which slows the growth and spread of herpes viruses in the body. Valacyclovir does not cure herpes infections, but it can shorten outbreaks, ease symptoms, and reduce how often outbreaks occur. It is taken by mouth as a tablet, typically with or without food.

What Does Valacyclovir 500mg Treat?

Cold sores (herpes labialis) in adults and children 12 and older
Genital herpes — initial episodes in adults
Genital herpes — recurrent episodes in adults
Genital herpes — daily suppressive therapy in adults
Reduction of genital herpes transmission in adults
Shingles (herpes zoster) in adults
Chickenpox (varicella) in children 2 to under 18 years

Valacyclovir 500mg Dosage

Cold sores: 2 g PO every 12 hours x 2 doses (1 day)
Genital herpes (initial): 1 g PO twice daily x 10 days; (recurrent): 500 mg PO twice daily x 3 days; (suppression): 1 g PO once daily
Shingles: 1 g PO three times daily x 7 days

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Valacyclovir 500mg Side Effects

Common side effects

  • Headache
  • Nausea
  • Abdominal pain
  • Dizziness
  • Vomiting
  • Fatigue
  • Sore throat

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

  • Signs of kidney problems (decreased urination, swelling)
  • Confusion, hallucinations, or agitation, especially in older adults
  • Seizures
  • Unusual bruising, bleeding, or extreme fatigue (possible TTP/HUS)
  • Severe allergic reaction (rash, swelling, trouble breathing)

Warnings & Interactions

Do not use if allergic to valacyclovir or acyclovir
Acute kidney failure can occur; dose adjustment needed in renal impairment
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) reported in immunocompromised patients
Central nervous system effects (confusion, hallucinations) more likely in elderly or those with kidney disease
Stay adequately hydrated while taking this medication
Use caution with other nephrotoxic drugs; tell your provider all medications you take
Does not cure herpes or fully eliminate the risk of transmitting it to others

Tell your prescriber about all medications, supplements, and health conditions before starting valacyclovir 500mg.

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Frequently Asked Questions

What is valacyclovir used for?

Valacyclovir is an antiviral used to treat cold sores, genital herpes, and shingles in adults, and cold sores and chickenpox in certain pediatric age groups. It helps shorten outbreaks and relieve symptoms but does not cure herpes infections.

Is valacyclovir the same as Valtrex?

Yes. Valacyclovir is the generic version of the brand-name drug Valtrex. Both contain the same active ingredient and work the same way.

Do I need a prescription for valacyclovir?

Yes. Valacyclovir is a prescription-only medication in the United States. A licensed healthcare provider must review your health information and issue a prescription before the pharmacy can dispense it.

How does ordering and shipping work?

After you complete a brief health questionnaire, a licensed provider reviews your information. If a prescription is appropriate, it is filled and shipped from a licensed U.S. pharmacy directly to your address.

How quickly should I start valacyclovir?

It works best when started as early as possible — at the first sign of a cold sore (tingling, itching, burning), within 72 hours of a shingles rash, or within 24 hours of genital herpes symptoms. Follow your provider's instructions on timing and duration.

Can valacyclovir prevent spreading genital herpes?

Daily suppressive therapy can reduce the risk of transmitting genital herpes to a partner, but it does not eliminate the risk. Safer sex practices are still recommended, and you should discuss prevention with your provider.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up on doses; contact your pharmacist if you are unsure.