Atovaquone/Proguanil 250mg/100mg
Generic For: Malarone
Atovaquone/proguanil 250mg/100mg, sold under the brand name Malarone, is a prescription antimalarial combination tablet. It is used to prevent malaria in travelers to at-risk regions and to treat acute, uncomplicated malaria caused by Plasmodium falciparum. After a licensed provider reviews your information, your order ships from a licensed U.S. pharmacy.
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Buy Atovaquone/Proguanil 250mg/100mg (Malarone) Online
An antimalarial combination tablet for the prevention and treatment of malaria, including chloroquine-resistant Plasmodium falciparum
Atovaquone/Proguanil 250mg/100mg Quick Facts
| Drug class | Antimalarial combination |
|---|---|
| Treats | Malaria prevention, acute uncomplicated P. falciparum malaria |
| Form | Tablet |
| Typical dosing | For traveling use. take 1 tablet daily start 1-2 days before trip and continue until 7 days after arriving back home. |
| Prescription required | Yes — prescription only |
What Is Atovaquone/Proguanil 250mg/100mg?
Atovaquone/proguanil is a fixed-dose combination tablet containing two antimalarial medicines that work together to stop the malaria parasite from multiplying. It is FDA-approved to prevent malaria, including in areas where chloroquine-resistant Plasmodium falciparum is present, and to treat acute, uncomplicated P. falciparum malaria. Travelers typically start taking it shortly before entering a malaria-risk area and continue for a week after leaving. It is taken by mouth once daily with food or a milky drink to improve absorption.
What Does Atovaquone/Proguanil 250mg/100mg Treat?
Prevention of Plasmodium falciparum malaria
Prevention of malaria in areas with chloroquine-resistant P. falciparum
Treatment of acute, uncomplicated P. falciparum malaria
Malaria prophylaxis for travelers to endemic regions
Atovaquone/Proguanil 250mg/100mg Dosage
Prophylaxis: 1 tablet (250mg/100mg) by mouth once daily with food; start 1–2 days before travel, continue daily during travel and for 7 days after leaving the malaria area.
Treatment: 4 tablets (1,000mg/400mg) by mouth once daily with food for 3 consecutive days.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Atovaquone/Proguanil 250mg/100mg Side Effects
Common side effects
- Headache
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Dizziness
- Mouth ulcers
- Abnormal dreams
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Severe allergic reaction (anaphylaxis, angioedema)
- Severe skin reactions (Stevens-Johnson syndrome, erythema multiforme)
- Hepatitis or elevated liver enzymes
- Severe or persistent vomiting or diarrhea (may reduce absorption)
- Signs of worsening or recurrent malaria (fever, chills)
Warnings & Interactions
Do not use for prophylaxis in patients with severe renal impairment (CrCl <30 mL/min)
Contraindicated with known hypersensitivity to atovaquone or proguanil
Not for treatment of severe or complicated malaria
Rifampin and rifabutin significantly reduce atovaquone levels; avoid coadministration
Tetracycline and metoclopramide may reduce atovaquone concentrations
Redose if vomiting occurs within 1 hour of taking a dose
May increase INR in patients taking warfarin; monitor closely
Tell your prescriber about all medications, supplements, and health conditions before starting atovaquone/proguanil 250mg/100mg.
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