Dapsone 25mg
Generic For: Aczone
Dapsone is a prescription sulfone antibacterial medication used to treat dermatitis herpetiformis and leprosy (Hansen's disease). The 25mg tablet allows flexible dosing under a provider's direction. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.
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Dapsone (Aczone) is a sulfone antibacterial used to treat dermatitis herpetiformis and leprosy (Hansen's disease).
Dapsone 25mg Quick Facts
| Drug class | Sulfone antibacterial |
|---|---|
| Treats | Dermatitis herpetiformis, leprosy (Hansen's disease) |
| Form | Tablet |
| Typical dosing | Take 1-2 tablet(s) by mouth daily |
| Prescription required | Yes — prescription only |
What Is Dapsone 25mg?
Dapsone is an oral sulfone antibacterial medication that has been used for decades to treat certain skin and infectious conditions. It is FDA-approved for dermatitis herpetiformis, a chronic blistering skin condition, and for leprosy (Hansen's disease), where it is typically combined with other medications. Dapsone works by interfering with bacterial folic acid synthesis and by reducing inflammation in the skin. The 25mg tablet strength allows providers to fine-tune dosing to the lowest effective amount.
What Does Dapsone 25mg Treat?
Dermatitis herpetiformis
Leprosy (Hansen's disease), as part of combination therapy
Lepromatous leprosy
Tuberculoid leprosy
Borderline leprosy
Dapsone 25mg Dosage
Dermatitis herpetiformis: 50 mg by mouth once daily; adjust as directed (range 50–300 mg daily); reduce to minimum effective dose.
Leprosy: 100 mg by mouth once daily, in combination with other antileprosy drugs, for the duration directed by your provider.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Dapsone 25mg Side Effects
Common side effects
- Nausea
- Vomiting
- Loss of appetite
- Headache
- Dizziness
- Skin rash
- Insomnia
- Blurred vision
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Hemolytic anemia (fatigue, pale skin, dark urine)
- Methemoglobinemia (bluish lips or skin, shortness of breath)
- Agranulocytosis (fever, sore throat, unusual infections)
- Severe skin reactions or hypersensitivity (dapsone syndrome)
- Liver injury (jaundice, dark urine, abdominal pain)
- Peripheral neuropathy (numbness, weakness in hands or feet)
Warnings & Interactions
Do not use if allergic to dapsone or other sulfones
G6PD deficiency increases risk of serious hemolysis; testing may be recommended before starting
Regular blood count monitoring is required during treatment
Stop and seek care for fever, rash, or jaundice (possible dapsone hypersensitivity syndrome)
Rifampin lowers dapsone levels; trimethoprim raises levels of both drugs
Use caution with other drugs that can cause hemolysis or methemoglobinemia
Tell your provider if you are pregnant or breastfeeding
Tell your prescriber about all medications, supplements, and health conditions before starting dapsone 25mg.
Sources & References
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