Metformin ER 1000mg
Generic For: Glucophage
Metformin ER 1000mg (extended-release, brand name Glucophage XR) is a first-line oral medication for type 2 diabetes that helps lower and control blood sugar. Metformin ER is taken once daily with the evening meal and works alongside diet and exercise. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.
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60-day supply · $0.58/tablet
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- Select your medication
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- Our licensed U.S. pharmacists fill your prescription
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Price: $35.00
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Buy Metformin ER 1000mg Online
Extended-release biguanide for type 2 diabetes and high blood sugar control
Metformin ER 1000mg Quick Facts
| Drug class | Biguanide antidiabetic |
|---|---|
| Treats | Type 2 diabetes, high blood sugar (glycemic control) |
| Form | Tablet |
| Typical dosing | Take 1 tablet by mouth once daily with the evening meal. |
| Prescription required | Yes — prescription only |
What Is Metformin ER 1000mg?
Metformin ER is the extended-release form of metformin, a biguanide medication used to improve blood sugar control in adults with type 2 diabetes mellitus. It works by decreasing the amount of glucose your liver produces, reducing glucose absorption from food, and improving your body's sensitivity to insulin. The extended-release tablet dissolves slowly, allowing once-daily dosing and often causing fewer stomach-related side effects than immediate-release metformin. It is used together with diet and exercise and does not treat type 1 diabetes.
What Does Metformin ER 1000mg Treat?
Type 2 diabetes mellitus in adults
Improving glycemic (blood sugar) control
Adjunct to diet and exercise
Used alone or with other antidiabetic medications
Used with insulin when additional control is needed
Metformin ER 1000mg Dosage
Start: 500 mg PO once daily with the evening meal; titrate weekly as tolerated.
Usual maintenance: 1000–2000 mg PO once daily with the evening meal.
Maximum: 2000 mg per day. Swallow tablets whole; do not crush or chew.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Metformin ER 1000mg Side Effects
Common side effects
- Diarrhea
- Nausea
- Upset stomach or indigestion
- Gas (flatulence)
- Abdominal discomfort
- Headache
- Metallic taste
- Decreased vitamin B12 levels with long-term use
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Lactic acidosis (muscle pain, trouble breathing, unusual tiredness, stomach pain) — rare but life-threatening
- Hypoglycemia, especially when combined with insulin or sulfonylureas
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Signs of vitamin B12 deficiency (numbness, tingling, anemia)
- Severe or persistent vomiting or dehydration
Warnings & Interactions
Boxed warning: risk of lactic acidosis — seek emergency care for symptoms
Contraindicated in severe kidney impairment (eGFR below 30 mL/min/1.73 m²)
Contraindicated in metabolic acidosis, including diabetic ketoacidosis
Temporarily stop before iodinated contrast imaging procedures in at-risk patients
Avoid excessive alcohol use — increases lactic acidosis risk
Use caution with kidney impairment, liver disease, or heart failure
Monitor vitamin B12 levels during long-term treatment
Tell your prescriber about all medications, supplements, and health conditions before starting metformin er 1000mg.
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