What is ondansetron ODT used for?

Ondansetron ODT is used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking serotonin, a natural substance that can trigger nausea and vomiting.

How do I take ondansetron ODT?

With dry hands, peel back the foil and place the tablet on top of your tongue, where it dissolves in seconds; swallow with saliva — no water is needed. Take it exactly as your provider prescribes, typically before chemotherapy, radiation, or surgery.

Do I need a prescription for ondansetron ODT?

Yes. Ondansetron ODT is a prescription-only medication in the United States. A licensed provider must review your health information and issue a valid prescription before it can be dispensed.

How does ordering and shipping work?

After you place your order, a licensed provider reviews your prescription and health information. Once approved, your medication is filled and shipped from a licensed U.S. pharmacy in discreet packaging.

Is ondansetron ODT the same as Zofran?

Yes. Ondansetron is the generic name for the brand-name medication Zofran ODT. Both contain the same active ingredient and work the same way.

How quickly does ondansetron ODT work?

The tablet dissolves on the tongue within seconds, and the medication typically begins working within about 30 minutes to 2 hours. It is usually taken before the event expected to cause nausea, such as chemotherapy or surgery.

What should I avoid while taking ondansetron ODT?

Avoid apomorphine, and tell your provider about all medications you take, especially antidepressants and other drugs that affect serotonin or heart rhythm. Contact your provider promptly if you experience palpitations, fainting, or symptoms of serotonin syndrome.

Ondansetron ODT 4mg

Name: Ondansetron ODT 4mg
Brand: All Family Pharmacy
SKU: ondansetron-odt-4mg
Availability: InStock

Generic For: Zofran

4.8 Google Star Rated · 200,000+ Orders Shipped

Ondansetron ODT 4mg — All Family Pharmacy

Ondansetron ODT 4mg (brand name Zofran) is an orally disintegrating tablet used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It dissolves on the tongue without water, making it easy to take when you feel nauseated. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.

Compare all Ondansetron options →

Select Quantity *

30 Tablets 60 Tablets 90 Tablets

5-day supply · $0.67/tablet

How It Works

Select your medication
Licensed providers review & prescribe
Our licensed U.S. pharmacists fill your prescription
Delivered to you as soon as the next day

Price: $20.00

HSA/FSA Eligible

Get Started

*Doctor visit fee & delivery cost not included in price. Refills at provider discretion.

Pharmacist Support Fast Shipping Licensed U.S. Pharmacy

Buy Ondansetron ODT 4mg Online

Ondansetron ODT is a 5-HT3 antagonist antiemetic that helps prevent nausea and vomiting from chemotherapy, radiation, and surgery.

Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge

Ondansetron ODT 4mg Quick Facts

Drug class	5-HT3 receptor antagonist antiemetic
Treats	Chemotherapy-induced nausea, radiation-induced nausea, postoperative nausea and vomiting
Form	Tablet
Typical dosing	Place 1 tablet on the tongue and allow to dissolve every 4 to 6 hours as needed for nausea. If nausea occurs with food or pills, take 1 tablet 30 minutes before.
Prescription required	Yes — prescription only

What Is Ondansetron ODT 4mg?

Ondansetron ODT is an orally disintegrating tablet form of ondansetron, sold under the brand name Zofran. It belongs to a class of medicines called 5-HT3 receptor antagonists, which block serotonin signals in the gut and brain that trigger nausea and vomiting. Because the tablet dissolves quickly on the tongue, it can be taken without water — helpful for people who have trouble swallowing or keeping liquids down. It is FDA-approved to prevent nausea and vomiting related to chemotherapy, radiation therapy, and surgery.

What Does Ondansetron ODT 4mg Treat?

Prevention of nausea and vomiting from moderately emetogenic chemotherapy
Prevention of nausea and vomiting from highly emetogenic chemotherapy
Prevention of nausea and vomiting from radiation therapy
Prevention of postoperative nausea and vomiting
Prevention of nausea from total body irradiation
Prevention of nausea from single high-dose radiotherapy to the abdomen

Ondansetron ODT 4mg Dosage

Moderately emetogenic chemotherapy: 8 mg by mouth 30 minutes before chemotherapy, then 8 mg 8 hours later; then 8 mg every 12 hours for 1–2 days after chemotherapy.
Radiation therapy: 8 mg by mouth 1–2 hours before each fraction of radiotherapy.
Postoperative nausea and vomiting: 16 mg by mouth 1 hour before induction of anesthesia.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Ondansetron ODT 4mg Side Effects

Common side effects

Headache
Constipation
Diarrhea
Fatigue or drowsiness
Dizziness
Dry mouth
Fever

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

Irregular heartbeat or QT prolongation (fainting, palpitations)
Signs of serotonin syndrome (agitation, fast heart rate, fever, muscle rigidity)
Severe allergic reaction (rash, swelling of face or throat, trouble breathing)
Severe constipation or signs of bowel blockage
Chest pain or shortness of breath

Warnings & Interactions

Do not use with apomorphine (risk of severe low blood pressure and loss of consciousness)
Do not use if allergic to ondansetron or other 5-HT3 antagonists
Can prolong the QT interval; avoid in congenital long QT syndrome and use caution with other QT-prolonging drugs
Risk of serotonin syndrome, especially with SSRIs, SNRIs, MAOIs, or other serotonergic drugs
May mask a progressive ileus or gastric distension after abdominal surgery
Use caution in patients with liver impairment (dose limits apply)
ODT tablets contain phenylalanine; use caution in phenylketonuria

Tell your prescriber about all medications, supplements, and health conditions before starting ondansetron odt 4mg.