Promethazine HCL 25mg
Generic For: Phenergan
Promethazine HCL 25mg (brand name Phenergan) is a prescription phenothiazine antihistamine used to relieve allergy symptoms, prevent and treat nausea and vomiting, and prevent motion sickness. It may also be used for short-term sedation before or after certain procedures. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.
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10-day supply · $0.67/tablet
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An antihistamine tablet for allergies, nausea and vomiting, and motion sickness
Promethazine HCL 25mg Quick Facts
| Drug class | Phenothiazine antihistamine |
|---|---|
| Treats | Allergies, nausea and vomiting, motion sickness, sedation |
| Form | Tablet |
| Typical dosing | Take 1 tablet by mouth every 4 to 6 hours as needed for nausea. If nausea occurs with food or pills, take 1 tablet 30 minutes before. |
| Prescription required | Yes — prescription only |
What Is Promethazine HCL 25mg?
Promethazine HCL is a first-generation phenothiazine antihistamine available as a 25mg tablet under the brand name Phenergan. It works by blocking histamine (H1) receptors, which helps relieve allergic symptoms such as runny nose, itching, and hives. It also acts on the brain's vomiting center, making it useful for nausea, vomiting, and motion sickness. Because promethazine HCL causes drowsiness, it is sometimes prescribed for short-term sedation.
What Does Promethazine HCL 25mg Treat?
Seasonal and perennial allergic rhinitis
Allergic conjunctivitis
Hives (urticaria) and other allergic skin reactions
Prevention and treatment of nausea and vomiting
Prevention of motion sickness
Preoperative and postoperative sedation
Adjunct to epinephrine in anaphylaxis (after acute symptoms are controlled)
Promethazine HCL 25mg Dosage
Allergy: 25 mg by mouth at bedtime; or 12.5 mg before meals and at bedtime as needed
Motion sickness: 25 mg by mouth 30–60 minutes before travel; may repeat in 8–12 hours
Nausea/vomiting: 12.5–25 mg by mouth every 4–6 hours as needed
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Promethazine HCL 25mg Side Effects
Common side effects
- Drowsiness or sedation
- Dizziness
- Dry mouth
- Blurred vision
- Constipation
- Confusion or disorientation
- Restlessness
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Slowed or shallow breathing (respiratory depression)
- Neuroleptic malignant syndrome (high fever, muscle rigidity, confusion)
- Uncontrollable muscle movements (extrapyramidal symptoms, tardive dyskinesia)
- Seizures
- Severe skin reactions or jaundice
- Low white blood cell counts (fever, sore throat, signs of infection)
Warnings & Interactions
Boxed warning: do not use in children under 2 years due to risk of fatal respiratory depression
Use the lowest effective dose in children 2 years and older
Avoid alcohol and other CNS depressants, including opioids and sedatives
May impair alertness — use caution when driving or operating machinery
Use caution with asthma, sleep apnea, glaucoma, or prostate enlargement
Contraindicated in comatose states and with prior hypersensitivity to phenothiazines
May lower the seizure threshold; use caution in patients with seizure disorders
Tell your prescriber about all medications, supplements, and health conditions before starting promethazine hcl 25mg.
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