What is ondansetron ODT used for?

Ondansetron ODT is used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking serotonin, a substance in the body that can trigger nausea and vomiting.

How do I take ondansetron ODT?

With dry hands, peel back the foil and place the tablet on your tongue, where it dissolves in seconds and can be swallowed with saliva — no water needed. Do not push the tablet through the foil, and take it exactly as your provider prescribed.

Do I need a prescription for ondansetron ODT?

Yes. Ondansetron ODT is a prescription-only medication in the United States. A licensed provider must review your health information and issue a valid prescription before the pharmacy can dispense it.

How does ordering and shipping work?

After you place your order, a licensed provider or pharmacist reviews your prescription and health details. Once approved, your medication is dispensed and shipped from a licensed U.S. pharmacy directly to your address.

How fast does ondansetron ODT work?

Ondansetron typically begins working within about 30 minutes to 2 hours. For chemotherapy or radiation, it is usually taken before treatment to prevent nausea rather than to stop it once it starts.

What is the difference between ondansetron ODT and regular ondansetron tablets?

Both contain the same active ingredient. The ODT (orally disintegrating tablet) dissolves on the tongue without water, which can be easier to take if you are nauseated or have trouble swallowing pills.

Can I take ondansetron ODT with other medications?

Ondansetron can interact with certain drugs, including apomorphine, SSRIs and other serotonergic medications, tramadol, and drugs that affect heart rhythm. Always tell your provider and pharmacist about everything you take before starting ondansetron.

Ondansetron ODT 8mg

Name: Ondansetron ODT 8mg
Brand: All Family Pharmacy
SKU: ondansetron-odt-8mg
Availability: InStock

Generic For: Zofran ODT

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Ondansetron ODT 8mg — All Family Pharmacy

Ondansetron ODT (the orally disintegrating form of Zofran) is a prescription antiemetic used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. The 8mg tablet dissolves on the tongue without water, making it easier to take when you feel sick. After a licensed provider reviews your prescription, your order ships from a licensed U.S. pharmacy.

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An anti-nausea (antiemetic) medication for nausea and vomiting caused by chemotherapy, radiation therapy, and surgery

Medically reviewed by David Paul Mackarey, RPh, Pharmacist-in-Charge

Ondansetron ODT 8mg Quick Facts

Drug class	5-HT3 receptor antagonist (antiemetic)
Treats	Chemotherapy-induced nausea, radiation-induced nausea, post-surgical nausea and vomiting
Form	Tablet
Typical dosing	Place 1 tablet on the tongue and allow to dissolve every 6 hours as needed for nausea.
Prescription required	Yes — prescription only

What Is Ondansetron ODT 8mg?

Ondansetron ODT is a prescription medication that prevents nausea and vomiting. It belongs to a class of drugs called 5-HT3 receptor antagonists, which work by blocking serotonin, a natural substance that can trigger nausea and vomiting signals in the brain and gut. The ODT (orally disintegrating tablet) form dissolves quickly on the tongue without water, which is helpful when swallowing pills is difficult. It is the generic version of Zofran ODT.

What Does Ondansetron ODT 8mg Treat?

Prevention of nausea and vomiting from chemotherapy
Prevention of nausea and vomiting from radiation therapy
Prevention of nausea and vomiting after surgery
Prevention of nausea from highly emetogenic cancer treatments
Prevention of nausea from moderately emetogenic cancer treatments

Ondansetron ODT 8mg Dosage

Chemotherapy (moderately emetogenic): 8mg by mouth 30 minutes before chemotherapy, then 8mg 8 hours later, then 8mg every 12 hours for 1-2 days after treatment.
Radiation therapy: 8mg by mouth 1-2 hours before radiation, then 8mg every 8 hours as directed.
Place tablet on tongue to dissolve; do not chew or swallow whole. Handle with dry hands.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Ondansetron ODT 8mg Side Effects

Common side effects

Headache
Constipation
Diarrhea
Fatigue or drowsiness
Dizziness
Dry mouth

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

Irregular heartbeat or QT prolongation (fainting, palpitations)
Signs of serotonin syndrome (agitation, rapid heartbeat, fever, muscle stiffness)
Severe allergic reaction (rash, swelling of face or throat, trouble breathing)
Chest pain
Masking of a progressive bowel obstruction (worsening abdominal pain or swelling)

Warnings & Interactions

Do not use with apomorphine (risk of severe low blood pressure and loss of consciousness)
Avoid in patients with congenital long QT syndrome; ECG monitoring may be needed with electrolyte abnormalities or heart conditions
Risk of serotonin syndrome when combined with SSRIs, SNRIs, MAOIs, or other serotonergic drugs
Do not use if allergic to ondansetron or other 5-HT3 antagonists
ODT tablets contain phenylalanine — use caution with phenylketonuria (PKU)
May mask symptoms of bowel obstruction after abdominal surgery
Tell your provider about all medications, including tramadol and heart rhythm drugs

Tell your prescriber about all medications, supplements, and health conditions before starting ondansetron odt 8mg.