Progesterone 100mg

Generic For: Prometrium

Progesterone 100mg (brand name Prometrium) is a bioidentical progestin hormone in capsule form. It is FDA-approved to prevent endometrial hyperplasia in postmenopausal women taking estrogen and to treat secondary amenorrhea (absence of menstrual periods). After a licensed provider reviews your prescription, your medication ships from a licensed U.S. pharmacy.

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100-day supply · $0.75/capsule

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  3. Our licensed U.S. pharmacists fill your prescription
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Price: $75.00

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Buy Progesterone 100mg (Prometrium) Online

A progestin hormone capsule used for endometrial hyperplasia prevention and secondary amenorrhea

Progesterone 100mg Quick Facts

Drug classProgestin (hormone)
TreatsEndometrial hyperplasia prevention, secondary amenorrhea
FormCapsule
Typical dosingTake 1 capsule by mouth daily.
Prescription requiredYes — prescription only

What Is Progesterone 100mg?

Progesterone is a naturally occurring female hormone that helps regulate the uterine lining and the menstrual cycle. The 100mg capsule, sold under the brand name Prometrium, contains micronized progesterone that is structurally identical to the hormone your body produces. It is commonly prescribed alongside estrogen in postmenopausal hormone therapy to protect the uterine lining, and it is also used to restore menstrual periods in women with secondary amenorrhea. Progesterone capsules require a prescription from a licensed healthcare provider.

What Does Progesterone 100mg Treat?

Prevention of endometrial hyperplasia in postmenopausal women receiving estrogen
Treatment of secondary amenorrhea (absence of menstrual periods)

Progesterone 100mg Dosage

Endometrial hyperplasia prevention: 200 mg by mouth once daily at bedtime for 12 sequential days per 28-day cycle, with daily estrogen.
Secondary amenorrhea: 400 mg by mouth once daily at bedtime for 10 days.

Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.

Progesterone 100mg Side Effects

Common side effects

  • Dizziness
  • Drowsiness
  • Headache
  • Breast tenderness
  • Abdominal pain or bloating
  • Fatigue
  • Mood changes or irritability
  • Nausea

Serious side effects

Stop taking this medication and seek medical attention right away if you experience:

  • Signs of blood clot (leg pain/swelling, chest pain, shortness of breath)
  • Stroke symptoms (sudden weakness, vision changes, severe headache)
  • Allergic reaction (rash, swelling, difficulty breathing)
  • Depression or significant mood changes
  • Jaundice (yellowing of skin or eyes)
  • Unusual or heavy vaginal bleeding

Warnings & Interactions

Contains peanut oil — do not use if allergic to peanuts
Do not use with undiagnosed abnormal vaginal bleeding
Do not use with known or suspected breast cancer or history of hormone-sensitive cancer
Do not use with active or prior blood clots, stroke, or heart attack
Do not use with liver disease or impaired liver function
Combined estrogen-progestin therapy may increase risk of heart attack, stroke, blood clots, breast cancer, and dementia (boxed warning)
May cause drowsiness or dizziness — take at bedtime and use caution driving

Tell your prescriber about all medications, supplements, and health conditions before starting progesterone 100mg.

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Frequently Asked Questions

What is progesterone used for?

Progesterone capsules are FDA-approved to prevent thickening of the uterine lining (endometrial hyperplasia) in postmenopausal women taking estrogen, and to treat secondary amenorrhea. Your provider may determine whether it is appropriate for your specific situation.

Do I need a prescription for progesterone?

Yes. Progesterone 100mg capsules are a prescription-only medication in the United States. A licensed healthcare provider must review your health history and issue a valid prescription before the pharmacy can dispense it.

How does ordering and shipping work?

After you place your order, a licensed provider or pharmacist reviews your prescription and health information. Once approved, your medication is dispensed and shipped directly to you from a licensed U.S. pharmacy.

Is progesterone the same as Prometrium?

Yes. Prometrium is the brand name for micronized progesterone capsules. The capsules contain progesterone that is structurally identical to the hormone naturally produced by the body.

When should I take progesterone capsules?

Progesterone is typically taken once daily at bedtime because it can cause drowsiness or dizziness. Follow the exact schedule your provider prescribes, as timing and duration differ by indication.

Can I take progesterone if I have a peanut allergy?

No. Prometrium and generic progesterone capsules contain peanut oil and should not be used by anyone with a peanut allergy. Tell your provider about all allergies before starting this medication.

What are the most common side effects of progesterone?

Common side effects include dizziness, drowsiness, headache, breast tenderness, bloating, and fatigue. Contact your provider promptly if you experience signs of a blood clot, severe headache, vision changes, or unusual vaginal bleeding.