Spironolactone 50mg
Generic For: Aldactone
Spironolactone 50mg (brand name Aldactone) is a potassium-sparing diuretic used to treat heart failure, high blood pressure, and fluid retention caused by conditions such as liver or kidney disease. After a licensed provider reviews your prescription, your order ships directly from a licensed U.S. pharmacy.
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A potassium-sparing diuretic (aldosterone antagonist) for heart failure, high blood pressure, and fluid retention (edema)
Spironolactone 50mg Quick Facts
| Drug class | Potassium-sparing diuretic (aldosterone antagonist) |
|---|---|
| Treats | Heart failure, high blood pressure, edema, primary hyperaldosteronism |
| Form | Tablet |
| Typical dosing | Take 1 Tablet by mouth daily. |
| Prescription required | Yes — prescription only |
What Is Spironolactone 50mg?
Spironolactone is a prescription medication known as a potassium-sparing diuretic, or aldosterone antagonist. It works by blocking aldosterone, a hormone that causes the body to retain salt and water, helping the body remove excess fluid without losing potassium. Doctors prescribe spironolactone for heart failure, high blood pressure, fluid retention (edema), and primary hyperaldosteronism. It is available as a generic tablet and under the brand name Aldactone.
What Does Spironolactone 50mg Treat?
Heart failure with reduced ejection fraction (NYHA class III–IV)
High blood pressure (hypertension)
Edema associated with liver cirrhosis
Edema associated with nephrotic syndrome
Primary hyperaldosteronism (diagnosis and management)
Hypokalemia in patients who cannot use other treatments
Spironolactone 50mg Dosage
Heart failure: 25 mg by mouth once daily; may increase to 50 mg once daily if tolerated.
Hypertension: 25–100 mg by mouth daily, in single or divided doses.
Edema: 100 mg by mouth daily (range 25–200 mg), in single or divided doses.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Spironolactone 50mg Side Effects
Common side effects
- Increased urination
- Breast tenderness or enlargement (gynecomastia)
- Dizziness or lightheadedness
- Nausea or stomach upset
- Drowsiness
- Irregular menstrual periods
- Headache
- Leg cramps
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- High potassium levels (hyperkalemia) — muscle weakness, slow or irregular heartbeat
- Severe dizziness or fainting
- Signs of dehydration or electrolyte imbalance (extreme thirst, confusion)
- Decreased kidney function
- Severe skin reactions (rash, blistering, peeling)
- Allergic reaction (swelling of face, lips, or throat; trouble breathing)
Warnings & Interactions
Do not use with high potassium levels (hyperkalemia) or Addison's disease
Do not take with eplerenone or potassium supplements unless directed
Use caution with ACE inhibitors, ARBs, and other potassium-raising drugs
NSAIDs may reduce effectiveness and increase potassium risk
May increase lithium and digoxin levels — monitoring required
Requires periodic blood tests for potassium and kidney function
Avoid during pregnancy unless your provider advises otherwise
Tell your prescriber about all medications, supplements, and health conditions before starting spironolactone 50mg.
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