Tretinoin 0.05% Cream
Generic For: Retin-A
Tretinoin 0.05% cream, sold under the brand name Retin-A, is a prescription topical retinoid used to treat acne vulgaris and, in some formulations, fine facial wrinkles and uneven pigmentation. It works by increasing skin cell turnover to help clear pores and improve skin texture. After a licensed provider reviews your information, your medication ships from a licensed U.S. pharmacy.
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60-day supply · $2.25/gram
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Buy Tretinoin 0.05% Cream (Retin-A) Online
A topical retinoid for acne, fine wrinkles, and uneven skin tone
Tretinoin 0.05% Cream Quick Facts
| Drug class | Topical retinoid |
|---|---|
| Treats | Acne vulgaris, fine facial wrinkles, mottled hyperpigmentation |
| Form | Cream |
| Typical dosing | Apply a pea-sized amount to clean, dry affected area(s) once daily at bedtime. Avoid eyes, lips, and mucous membranes. |
| Prescription required | Yes — prescription only |
What Is Tretinoin 0.05% Cream?
Tretinoin is a topical form of vitamin A (a retinoid) applied to the skin as a cream. It speeds up the turnover of skin cells, which helps prevent pores from becoming clogged and reduces the formation of acne lesions. The 0.05% cream strength is commonly prescribed for acne vulgaris and is also used to improve the appearance of fine wrinkles and dark spots caused by sun damage. Results typically appear gradually over several weeks of consistent use.
What Does Tretinoin 0.05% Cream Treat?
Acne vulgaris
Comedonal acne (blackheads and whiteheads)
Inflammatory acne lesions
Fine facial wrinkles
Mottled hyperpigmentation (dark spots)
Rough facial skin texture
Tretinoin 0.05% Cream Dosage
Apply a thin layer to affected skin once daily at bedtime.
Wash and dry skin gently before applying; use a pea-sized amount for the face.
Improvement may take 6–12 weeks; continue as directed by your provider.
Your prescriber will determine the dose and duration that are right for you. Always follow the directions on your prescription label.
Tretinoin 0.05% Cream Side Effects
Common side effects
- Skin dryness
- Peeling or flaking
- Redness (erythema)
- Burning or stinging sensation
- Itching
- Increased sensitivity to sunlight
- Temporary worsening of acne early in treatment
Serious side effects
Stop taking this medication and seek medical attention right away if you experience:
- Severe blistering, crusting, or swelling of the skin
- Signs of allergic reaction (hives, facial swelling, trouble breathing)
- Severe or persistent skin irritation
- Severe sunburn reactions
Warnings & Interactions
Do not use if allergic to tretinoin or any ingredient in the cream
Avoid during pregnancy unless directed by your provider; discuss risks if pregnant or breastfeeding
Minimize sun exposure and use sunscreen; tretinoin increases photosensitivity
Avoid applying to eczema-affected, sunburned, or broken skin
Avoid concurrent use of harsh or drying products (astringents, strong exfoliants) unless advised
Keep away from eyes, mouth, nostrils, and mucous membranes
Use caution with other photosensitizing drugs (e.g., thiazides, tetracyclines, fluoroquinolones)
Tell your prescriber about all medications, supplements, and health conditions before starting tretinoin 0.05% cream.
Sources & References
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